Rapid synthesis of large enaminolactams, a novel class of macrocycles
An efficient preparation of enaminolactams using an original synthetic method based on the thermal decomposition of Meldrum's acids derivatives is reported. The key step involves an intramolecular addition of ω-aminoalkyl- aminomethyleneketenes.
Jourdain, Franck,Caron, Mireille,Pommelet, Jean Claude