227183-66-6Relevant articles and documents
Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p-carborane cages
Kaise, Asako,Ohta, Kiminori,Fujii, Shinya,Oda, Akifumi,Goto, Tokuhito,Endo, Yasuyuki
, p. 3805 - 3811 (2018)
Based on the co-crystal structure of bicalutamide with a T877A-mutated androgen receptor (AR), glycerol and aminoglycerol derivatives were designed and synthesized as a novel type of carborane-containing AR modulators. The (R)-isomer of 6c, whose chiralit
Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists
Sedlák, David,Wilson, Tyler A.,Tjarks, Werner,Radomska, Hanna S.,Wang, Hongyan,Kolla, Jayaprakash Narayana,Le?nikowski, Zbigniew J.,?pi?áková, Alena,Ali, Tehane,Ishita, Keisuke,Rakotondraibe, Liva Harinantenaina,Vibhute, Sandip,Wang, Dasheng,Anzenbacher, Pavel,Bennett, Chad,Bartunek, Petr,Coss, Christopher C.
, p. 9330 - 9353 (2021/07/20)
Selective agonism of the estrogen receptor (ER) subtypes, ERα and ERβ, has historically been difficult to achieve due to the high degree of ligand-binding domain structural similarity. Multiple efforts have focused on the use of classical organic scaffold
