- Impact of microwave radiations on macrocyclization reactions: Solvent free synthesis of 1,4-benzothiazin-3-one derivatives on basic alumina
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A rapid transformation of alkyl and arylalkyl amino phenyl thioethers (2-alkylsulphanyl-phenylamine) into 7-substituted 1,4-benzothiazines in presence of basic-alumina under solvent free conditions using microwave irradiation has been described. The specific microwave effects are due to increase in polarity during the course of reaction.
- Chhikara, Bhupender S.,Tandon, Vibha,Mishra, Anil K.
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- Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models
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A novel series of 7-alkoxy-2,4-dihydro-1H-benzo [b][1,2,4]triazolo[4,3-d] [1,4]-thiazin-1-ones have been synthesized and tested for their anticonvulsant activity using the maximal electroshock (MES) method. The majority of the compounds prepared were effe
- Cao, Xu,Wang, Shi-Ben,Deng, Xian-Qing,Liu, Da-Chuan,Quan, Zhe-Shan
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p. 1829 - 1838
(2014/05/06)
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- [NO3], a green and base-free medium for one-pot synthesis of benzothiazinones at room temperature
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A general and efficient room-temperature procedure is developed for high-yield synthesis of 2H-benzo[b][1,4]thiazin-3(4H)-one derivatives in one pot from the reaction of 2-aminothiophenols with 2-bromoalkanoates in ionic liquid [bmim]NO3 without the use of any catalyst, base, or additive. Products were obtained in good yields by simple extraction with Et2O followed by evaporation of the volatile contents and recrystallization from Et2O. The ionic liquid was recycled and reused in the next reaction without the loss of its activity.
- Sharifi, Ali,Abaee, M. Saeed,Rouzgard, Mahdiyeh,Mirzaei, Mojtaba
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p. 2079 - 2089
(2013/06/26)
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- Synthesis and anticonvulsant activity of some 7-alkoxy-2H-1,4-benzothiazin- 3(4H)-ones and 7-alkoxy-4H-[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazines
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A series of 7-alkoxy-2H-1,4-benzothiazin-3(4H)-ones and a new series of 7-alkoxy-4H-[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazine derivatives were synthesized using 5-methoxybenzo[d]thiazol-2-amine as starting material. The structures of the compounds were
- Zhang, Li-Qiu,Guan, Li-Ping,Wei, Cheng-Xi,Deng, Xian-Qing,Quan, Zhe-Shan
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experimental part
p. 326 - 331
(2011/02/25)
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- Designer ligands. Part 4. Synthesis of acyclic and macrocyclic platinum group metal-specific ligands
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Synthetic pathways to a range of novel, polydentate, sulfur-containing, mono-amide ligands, designed to coordinate platinum group metals, have been developed.Access to the tetradentate systems was facilitated by the extensive use of disulfide linkages as a protection strategy.
- Hagemann, Justin P.,Kaye, Perry T.
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p. 341 - 348
(2007/10/03)
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- 3-H-1,2,3-Benzodithiazole-2-oxides as synthons for the synthesis of five- and six-membered heterocycles containing sulphur and nitrogen
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The reaction of 6-substituted-1,2,3-benzodithiazole-2-oxides (2) with aromatic aldehydes, carboxylic acids and acid chlorides in the presence of an organic base such as triethylamine and N,N-dimethylaniline lead to the formation of 6-substituted-2-arylben
- Sawhney, S N,Sharma, P. K.,Bajaj, K,Gupta, A
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p. 280 - 284
(2007/10/02)
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- Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide
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Evaluation of a series of lactam heterocyclic analogues of cilostamide as inhibitors of cyclic AMP phosphodiesterase derived from both human platelets and rat heart in comparison with their corresponding methoxy-substituted heterocycles has revealed that the N-cyclohexyl-N-methyl-4-oxybutyramide side chain of 2 is an important lipophilic and/or steric pharmacophore. Attachment of this side chain to the parent heterocycle of the potent cyclic AMP phosphodiesterase inhibitor anagrelide afforded the hybrid structure RS-82856, shown to be more potent than either of its progenitors as an inhibitor of cyclic AMP phosphodiesterase or of ADP-induced platelet aggregation. The available in vitro data suggest that 1 possesses potentially useful antithrombotic and cardiotonic properties.
- Jones,Venuti,Alvarez,Bruno,Berks,Prince
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p. 295 - 303
(2007/10/02)
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