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2292-16-2

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Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera
Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.
Nishimura, Katsumi,Horii, Shinji,Tanahashi, Takao,Sugimoto, Yumi,Yamada, Jun
p. 59 - 68
(2013/02/23)

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Chemical Properties

Melting Point: 59-61 °C
Boiling Point: 710.931 °C at 760 mmHg
Flash Point:383.758 °C
Density: 1.186 g/cm³
Solubility:DMSO: >15mg/mL
Storage Temp.:2-8°C
Vapor Pressure: 6.97E-21mmHg at 25°C
Refractive Index: 1.601
PKA: 9.28±0.45(Predicted)
PSA: 72.86000
LogP: 6.63810

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