- A Unified Approach to the Isomeric α-, β-, γ-, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts
-
A cross-coupling/reductive cyclization protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which is readily prepared through an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-tetrahydro-α-carboline that is itself readily aromatized to give α-carboline (1).
- Yan, Qiao,Gin, Emma,Banwell, Martin G.,Willis, Anthony C.,Carr, Paul D.
-
p. 4328 - 4335
(2017/04/28)
-
- PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5
-
The present invention provides ALK5 inhibitors of the formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, methods of making the compounds and intermediates thereof; and methods of using the compounds.
- -
-
-