2-Pyridylphosphonates: A new type of modification for nucleotide analogues
Suitably protected dithymidine H-phosphonates afforded the corresponding dinucleoside 2-pyridylphosphonates upon treatment with N-methoxypyridinium tosylate in acetonitrile in the presence of 1,8-diazabicylo[5.4.0]undec-7-ene (DBU). The reaction was rapid (ca. 5 min), practically quantitative and proceeded stereospecifically, most likely with retention of configuration at the phosphorus centre.
Johansson, Tommy,Kers, Annika,Stawinski, Jacek
p. 2217 - 2220
(2007/10/03)
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