ELECTROPHILIC AND NUCLEOPHILIC SUBSTITUTION IN OXAZOLOXANTHINES
Bromination of 2-aryloxazoloxanthines gives the 3-bromoderivatives whereas 8-methyl-2-phenyloxazoloxanthine is nitrated in the para-position of the phenyl substituent.Alkylation of oxazoloxanthines by ethylmonoiodoacetate gives the ethyl esters of oxazoloxanthinyl-6-acetic acids.Reaction of oxazoloxanthines with sodium sulfide gives thiazoloxanthines whereas the reaction with secondary amines opens the oxazole ring.
Garmash, S. N.,Skul'skaya, E. A.,Priimenko, B. A.,Klyuev, N. A.
p. 1164 - 1167
(2007/10/02)
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