- Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes
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The previously known complexes [Ti{(Me2CMe2C) (η5-C5H4)2}Cl2] (1), [Ti{Me2C(η5-C5H4) 2}Cl2] (2), [Ti {Me2/
- Mijatovi?, Sanja,Bulatovi?, Mirna,Moji?, Marija,Sto?i?-Gruji?i?, Stanislava,Miljkovi?, Djordje,Maksimovi?-Ivani?, Danijela,Gómez-Ruiz, Santiago,Pinkas, Ji?í,Horá?ek, Michal,Kaluderovi?, Goran N.
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- Synthesis and properties of optically active organomolybdenum compounds
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The reaction of an optically active cyclopentadienyl salt, formed from the asymmetric reduction of 6-methyl-6-phenylfulvene, with Mo(CO)6 followed by treatment with N-methyl-N-nitroso-p-toluenesulfonamide, yields an optically active organomolybdenum compl
- Moriarty, Kevin J.,Rausch, Marvin D.
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- Kinetics and Mechanism of Pyrrolidine Buffer-Catalyzed Fulvene Formation
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Rapid synthesis of fulvenes is achieved using pyrrolidinium/pyrrolidine buffers in anhydrous acetonitrile. Time-dependent UV-vis absorption and NMR spectroscopy reveal that the rate and yield of fulvene formation depend strongly on both the presence of acid in the medium and the choice of solvent, and they are negatively affected by water. Kinetic data have been collected for various substrates, and the synthetic benefits of the adjusted reaction conditions are showcased. Enhancements of reaction rates are found in comparison to literature procedures. α-Unsaturated fulvenes that were previously difficult to access can now be obtained in good yields.
- Sieverding, Paul,Osterbrink, Johanna,Besson, Claire,K?gerler, Paul
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p. 486 - 494
(2019/01/11)
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- Preparation method of substituted cyclopentadienyl metallocene compound
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The invention relates to a preparation method of a substituted cyclopentadienyl metallocene compound. The preparation method comprises the following steps that a cyclopentadienyl compound and an aldehyde-ketone compound are adopted to carry out reaction to produce a fulvene compound, then the fulvene compound is acted with metal hydride to produce substituted cyclopentadienyl salt, and the substituted cyclopentadienyl salt is further reacted with group IV metal halide to produce the metallocene compound. Compared with the prior art, the preparation method has the advantages of high product yield, convenience in operation, good economy and the like and is suitable for industrial production.
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Paragraph 0090; 0091; 0092
(2017/11/30)
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- Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes
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The antitumor activity shown by many platinum complexes has produced a strong interest in research of new organometallic compounds having anticancer action. Among the many metal compounds synthesized and tested, those based on titanium have received consi
- Chimento, Adele,Saturnino, Carmela,Iacopetta, Domenico,Mazzotta, Rosaria,Caruso, Anna,Plutino, Maria Rosaria,Mariconda, Annaluisa,Ramunno, Anna,Sinicropi, Maria Stefania,Pezzi, Vincenzo,Longo, Pasquale
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p. 7302 - 7312
(2015/11/16)
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- An improved pathway to 6,6-disubstituted fulvenes
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Pentafulvenes with alkyl and/or aryl substituents at the exocyclic position are formed rapidly in high yields through reaction of crystalline sodium cyclopentadienide directly with the appropriate ketones.
- Chajara, Khalil,Ottosson, Henrik
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p. 6741 - 6744
(2007/10/03)
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- Tandem Reactions of N,N-Dialkylamides with Organolithium Compounds and Cyclopentadiene. A New Efficient Synthesis of Pentafulvenes
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Reactions of N,N-dialkylamides with organolithium compounds followed by addition of cyclopentadiene furnish 6-mono- or 6,6-di-substituted pentafulvenes in moderate to high yields, providing a new and simple pentafulvene synthesis.
- Kurata, Hiroyuki,Ekinaka, Tatsuya,Kawase, Takeshi,Oda, Masaji
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p. 3445 - 3448
(2007/10/02)
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- Conformational Effects on High-Spin Organic Molecules
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The ability of m-phenylene to ferromagnetically couple spin-containing substituents that are substantially twisted out of conjugation is investigated.The "bis(TMM)" strategy is employed, in which two triplet TMM biradicals are linked through m-phenylene to produce relatively stable, organic tetraradicals that are characterized by EPR spectroscopy.Under conditions of moderate twisting (4), ferromagnetic coupling is seen, and the tetraradical has a quintet ground state.Severely twisting both TMM as in 13 disrupts spin communication, and two noninteracting triplets are produced.This is in contrast to other highly twisted m-phenylene derivatives, in which antiferromagnetic coupling has been observed.Surprisingly, severely twisting only one TMM (14) still produces ferromagnetic coupling and a quintet ground state through a spin polarization mechanism analogous to that proposed for 90 deg C twisted ethylene.Several ring-constrained TMMs (17-19) are investigated as models for more nearly planar systems.
- Silverman, Scott K.,Dougherty, Dennis A.
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p. 13273 - 13283
(2007/10/02)
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- Generation, Characterization, and Reactions of Fulvene Dianions
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The dianion of 6,6-diphenylfulvene obtained by reduction with lithium metal was first characterized spectroscopically.Reduction of 6-dimethylamino-6-phenylfulvene also generated its dianion whose reactions with electrophiles led to 6-phenylfulvene derivat
- Kawase, Takeshi,Fujino, Shin-ichi,Oda, Masaji
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p. 1683 - 1686
(2007/10/02)
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- REACTION OF DICYCLOPENTADIENYLYTTRIUM CHLORIDE WITH ALDEHYDES AND KETONES. A NOVEL CLEAVAGE REACTION OF Cp-Y ?-BOND
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Dicyclopentadienylyttrium chloride reacts with aldehydes and ketones at 80 deg C in DME, generating fulvenes in excellent yields, while at lower temperature affording, after hydrolysis, cyclopentadienyl substituted alcohols.
- Qian, Changtao,Qiu, Aineng
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p. 6931 - 6934
(2007/10/02)
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