- Facile amide bond formation from esters of amino acids and peptides catalyzed by alkaline protease in anhydrous tert-butyl alcohol using ammonium chloride/triethylamine as a source of nucleophilic ammonia
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An industrial alkaline protease 'Alcalase', stable and active in tert-butyl alcohol, was used to catalyze the synthesis of N-protected amino acids or peptide amides in anhydrous tert-butyl alcohol using ammonium chloride/triethylamine as source of nucleophilic ammonia
- Chen,Jang,Wang
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p. 858 - 860
(2007/10/02)
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- Use of 2-pyrimidine thiol carbonates as acylating agents for amino or imino containing compounds
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Thiolcarbonates represented by the formula, SPC1 Wherein R1 and R2 are individually a hydrogen atom or a methyl group, and R3 is a straight chain or branched chain saturated or unsaturated alkyl group having 1 to 5 carbon atoms or is a benzyl or benzhydryl group which may be nuclear substituted, are quite useful for protecting the amino or imino groups of amines, hydrazines, amino acids and peptides with groups of the formula EQU1 The thiolcarbonates can be easily produced by reacting an alkali metal salt of 2-mercaptopyrimidine with phosgene, and reacting the resulting thiolchloroformate with an alcohol (R3 OH), or by reacting a 2-mercaptopyrimidine with a halocarbonic acid ester.
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