cas 23255-20-1, 3-PYRIDINECARBOXAMIDINE | Articles data ｜lookchem

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23255-20-1

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Barber,Slack
p. 1607
(1944)
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Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected the o
Ho, Koc-Kan,Auld, Douglas S.,Bohnstedt, Adolph C.,Conti, Paolo,Dokter, Wim,Erickson, Shawn,Feng, Daming,Inglese, Jim,Kingsbury, Celia,Kultgen, Steven G.,Liu, Rong-Qiang,Masterson, Christopher M.,Ohlmeyer, Michael,Rong, Yajing,Rooseboom, Martijn,Roughton, Andrew,Samama, Philippe,Smit, Martin-Jan,Son, Ellen,van der Louw, Jaap,Vogel, Gerard,Webb, Maria,Wijkmans, Jac,You, Ming
p. 2724 - 2728
(2007/10/03)

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Chemical Properties

Melting Point: 190 °C
Boiling Point: 240.7 °C at 760 mmHg
Flash Point:99.4 °C
Density: 1.22 g/cm³
Storage Temp.:2-8°C
PKA: 10.29±0.50(Predicted)
PSA: 62.76000
LogP: 1.96770

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