232612-30-5Relevant articles and documents
2-(aminomethyl)thiazolyl-5-nitrile and synthesis method thereof
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Paragraph 0008; 0025; 0038-0039; 0042; 0055-0056; 0059; 0072, (2020/11/12)
The invention belongs to the technical field of organic synthesis, and relates to 2-(aminomethyl)thiazolyl-5-nitrile and a synthesis method thereof. The method comprises the following steps: by takingaminoacetonitrile hydrochloride as a raw material, carrying out eight steps of reactions including substitution, amination, substitution, amination, Boc addition reaction, substitution, substitutionand Boc removal reaction to prepare the 2-(aminomethyl)thiazolyl-5-nitrile. An efficient synthesis method is provided for synthesis of the compound.
FACTOR XIIA INHIBITORS
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Paragraph 00281-00282, (2019/10/19)
This invention relates to compoundsof formula (I)and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.