- A diversified assembly of 1,2,4-oxadiazol-3-amines: Metallic thiophile catalyzed chemoselective one-pot reaction of aryl isothiocyanates, amidines/guanidines, and hydroxylamine
-
An efficient one-pot synthesis of 1,2,4-oxadiazol-3-amines from simple starting materials, isothiocyanates, amidines/guanidines, and hydroxylamine, is described. The reaction is facilitated by metallic-thiophile-assisted desulfurization of in situ formed amidino- or guanidinothiourea to give chemoselectively N-hydroxyguanidine intermediates that give exclusively various 1,2,4-oxadiazol-3-amines in good to excellent yields. The reaction mechanistic pathway may proceed through an intramolecular 5-exo-trig cyclization.
- Jalani, Hitesh B.,Sudarsanam, V.,Vasu, Kamala K.
-
p. 3378 - 3386,9
(2012/12/12)
-
- Photochemical Behaviour of Some 1,2,4-Oxadiazole Derivatives
-
The photochemical behaviour of some 1,2,4-oxadiazole derivatives in methanol has been studied at 254 nm.On irradiation, 3-amino- (or 3-methylamino-) 5-aryl-1,2,4-oxadiazoles underwent a ring photoisomerization to 1,3,4-oxadiazoles, probably through a 'rin
- Buscemi, Silvestre,Cicero, Maria G.,Vivona, Nicolo,Caronna, Tullio
-
p. 1313 - 1316
(2007/10/02)
-