A process of preparing (6S)-tetrahydrofolic acid derivatives comprising reacting racemic (6RS)-tetrahydrofolic acid derivatives with N-alkyl-D-glucamine, forming N-alkyl-D-glucamine salts of the (6RS)-tetrahydrofolic acid derivatives, isolation of the N-alkyl-D-glucamine salt of the (6S)-tetrahydrofolic acid derivative, removal of the N-alkyl-D-glucamine cation and purification of the (6S)-tetrahydrofolic acid derivative. The purified (6S)-tetrahydrofolic acid derivative can then be converted into the corresponding alkali metal or alkaline earth metal salts.
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Page/Page column 25; 26
(2013/03/26)
Resolution of ibuprofen
(S)-ibuprofen may be separated from a mixture of (S)-ibuprofen and (R)-ibuprofen in high yield and enantiomeric purity in a single resolution step using an N-alkyl-D-glucamine as the resolving agent.
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(2008/06/13)
Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
Mixtures of d 2-(6-methoxy-2-naphthyl)propionic acid and 1 2-(6-methoxy-2-naphthyl)propionic acid or soluble salts thereof are resolved with N-R-D-glucamine or salts thereof, where R is alkyl having 2 to 36 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, to yield a product substantially enriched in d 2-(6-methoxy-2-naphthyl)propionic acid.
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(2008/06/13)
Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
Mixtures of d 2-(6-methoxy-2-naphthyl)propionic acid and 1 2-(6-methoxy-2-naphthyl)propionic acid or soluble salts thereof are resolved with N-R-D-glucamine or salts thereof, where R is alkyl having 2 to 36 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, to yield a product substantially enriched in d 2-(6-methoxy-2-naphthyl)-propionic acid.
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(2008/06/13)
Chemical Properties
Appearance/Colour :white to light yellow crystal powder
Melting Point: 121-124 °C
Boiling Point: 524.7 °C at 760 mmHg
Flash Point:164.7 °C
Density: 1.139 g/cm3
Solubility:DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature