N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors
A class of N,N-dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)- benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines has been discovered as potent factor Xa inhibitors with desirable in vitro and in vivo anticoagulant activity
Jia, Zhaozhong J.,Su, Ting,Zuckett, Jingmei F.,Wu, Yanhong,Goldman, Erick A.,Li, Wenhao,Zhang, Penglie,Clizbe, Lane A.,Song, Yonghong,Bauer, Shawn M.,Huang, Wenrong,Woolfrey, John,Sinha, Uma,Arfsten, Ann E.,Hutchaleelaha, Athiwat,Hollenbach, Stanley J.,Lambing, Joseph L.,Scarborough, Robert M.,Zhu, Bing-Yan
This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..
-
Page/Page column 84
(2008/06/13)
Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.
Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed.
He, Wei,Hanney, Barbara,Myers, Michael R,Condon, Stephen,Becker, Michael R,Spada, Alfred P,Burns, Christopher,Brown, Karen,Colussi, Dennis,Chu, Valeria
p. 919 - 922
(2007/10/03)
More Articles about upstream products of 234108-34-0