- Tumor nano vaccine Preparation method and application thereof
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The invention relates to a tumor nano vaccine and a preparation method and application thereof. The tumor nano vaccine is a composite nano micelle composed of an acid sensitive polymer immunologic adjuvant conjugate and a tumor-related antigen/antigen peptide, and the acid sensitive polymer immunoadjuvant conjugate has the structure shown 1. The tumor nano vaccine can selectively target lymph nodes and efficiently deliver tumor neoantigen and immunologic adjuvant to dendritic cells, activate antigen-specific T-cell immune effect, and efficiently inhibit tumor growth and metastasis.
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Paragraph 0057-0059
(2021/11/03)
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- All-cell tumor nano vaccine Preparation method and application thereof
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The invention relates to a whole-cell tumor nano vaccine and a preparation method and application thereof. The whole-cell tumor nano vaccine is a nano-vaccine of an acid-sensitive polymer-loaded immunoadjuvant, a nano-vaccine of an acid-sensitive polymer - immunologic adjuvant conjugate, a nano vaccine coated with an engineering tumor cell membrane, or a combination of the two. To the whole-cell tumor nano vaccine, dendritic cell antigen presenting efficiency can be enhanced, multiple specific cytotoxic T lymphocytes are activated, efficient anti-tumor recurrence and transfer effects are achieved, and meanwhile, personalized treatment of malignant tumors is facilitated.
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Paragraph 0063-0065
(2021/11/21)
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- Phosphate cross-linking agent and preparation method thereof, phosphate-based cross-linked gel polymer electrolyte and preparation method and application thereof
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According to the invention, the safety of the battery can be improved based on introduction of phosphate into the gel polymer electrolyte, , the adjustable flexibility is improved by introduction of aPEO chain segment, and the stability and the polymerization capability are improved by introduction of acrylate; thus, further research is carried out on the basis of the prior art, the polyfunctional phosphate cross-linking agent is obtained and is applied to the preparation of the phosphate-based cross-linked gel polymer electrolyte, so the cross linking agent can be copolymerized with other functional monomers to synthesize gel polymer electrolyte; the gel polymer electrolyte has the advantages of simple and convenient preparation method, high ionic conductivity, high thermal stability andgood electrochemical stability, the assembled sodium ion battery has good cycling stability and high-temperature performance, and the phosphate-based gel polymer electrolyte with high safety is provided for quasi-solid sodium/lithium ion batteries.
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Paragraph 0047-0048; 0055
(2020/08/17)
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- Supramolecularly Engineered Amphiphilic Macromolecules: Molecular Interaction Overrules Packing Parameters
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We report molecular interaction-driven self-assembly of supramolecularly engineered amphiphilic macromolecules (SEAM) containing a single supramolecular structure-directing unit (SSDU) consisting of an H-bonding group connected to a naphthalene diimide chromophore. Two such SEAMs, P1-50 and P2-50, having the identical chemical structure and hydrophobic/hydrophilic balance, exhibit distinct self-assembled structures (polymersome and cylindrical micelle, respectively) due to a difference in the H-bonding group (hydrazide or amide, respectively) of the single SSDU. When mixed together, P1-50 and P2-50 adopted self-sorted assembly. For either series of polymers, variation in the hydrophobic/hydrophilic balance does not alter the morphology reconfirming that self-assembly is primarily driven by directional molecular interaction which is capable of overruling the existing norms in packing parameter-dependent morphology control in an immiscibility-driven block copolymer assembly.
- Pramanik, Prithankar,Ray, Debes,Aswal, Vinod K.,Ghosh, Suhrit
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supporting information
p. 3516 - 3520
(2017/03/21)
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- Protein-Grafted Polymers Prepared Through a Site-Specific Conjugation by Microbial Transglutaminase for an Immunosorbent Assay
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Protein-polymer conjugates have been developed in many fields. Most hybrids are composed of one protein attached to one or several polymer chains. The other form of hybrid involves the construction of multiple proteins on one polymer chain, thereby facili
- Wakabayashi, Rie,Yahiro, Kensuke,Hayashi, Kounosuke,Goto, Masahiro,Kamiya, Noriho
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p. 422 - 430
(2017/02/23)
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- PROTEIN-POLYMER COMPLEX, TGase SUBSTRATE-CONTAINING POLYMER, TGase SUBSTRATE-CONTAINING MONOMER, METHOD FOR PRODUCING PROTEIN-POLYMER COMPLEX, AND METHOD FOR IMPROVING PROTEIN FUNCTION ON INTERFACE OR IN VICINITIY OF INTERFACE OF SOLID-LIQUID
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Provided is a protein-polymer complex which is capable of detecting a target with good sensitivity. Specifically provided is a protein-polymer complex comprising a polymer having a glutamine (Gln) residue or a primary amine on a side chain, wherein either a protein having a primary amine is bound to the glutamine (Gln) residue, or a protein having a glutamine (Gln) residue is bound to the primary amine.
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Paragraph 0153; 0154; 0155
(2016/08/17)
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- Process for synthesis of Di(meth)acrylic acid esters
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A process for the synthesis and recovery of di(meth)acrylic acid esters at a high degree of purity. Di(meth)acrylic acid esters are produced by transesterfication of (meth)acrylic acid esters of C1to C4alcohols with 1,n-diols (where n≧3) in the presence of a zirconium catalyst that comprises a chelate of zirconium with a 1,3-dicarbonyl compound. These catalysts can be readily separated or removed from the reaction mixture by precipitation with phosphoric acid, thus providing a convenient and inexpensive method of producing a di(meth)acrylic acid ester with a reduced level of zirconium.
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Page/Page column 7
(2008/06/13)
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- Chromene compound
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A photochromic compound featuring a large fading rate to prevent a change in the color tone at the time of fading, exhibiting little color after aged, and exhibiting good durability in the photochromic property. The photochromic compound is a novel chromene compound having a substituted phenyl group at the second position of the naphthopyrane ring and an alkyl group at the fifth position thereof, and is represented by, for example, the following formula, wherein R1 is an alkyl group, R2 and R3 are substituted phenyl groups, and R4 and R5 are substituents.
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- Reaction kinetics of acyl chlorides with glycols
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The reaction rates of crotonyl and methacryloyl chlorides with mono-, di-, and triethylene glycols obey the second order equations. No isokinetic relation was observed.
- Baranovskaya
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p. 482 - 485
(2007/10/03)
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- Macrocyclic ethers by free radical cyclizations
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Tin hydride reduction of ω-iodo-polyoxaalkyl acrylates 1 using syringe pump addition of both reactants to a solution of AIBN in benzene at 80°C afforded the corresponding cyclic polyethers in excellent yields.
- Philippon, Annie,Tao, Jingchao,Tetard, David,Degueil-Castaing, Marie,Maillard, Bernard
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p. 2651 - 2682
(2007/10/03)
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- Kinetics of the Esterification of Triethylene Glycol by Methacrylic Acid
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In order to model catalysis by sulphonic acid cadion-exchange resins, the esterification of triethylene glycol by methacrylic acid has been studied experimentally in the presence of a large amount of catalyst (toluene-p-sulphonic acid).A mathematical model of the process is proposed.
- Onishchenko, V. V.,Gantman, A. I.
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p. 1132 - 1134
(2007/10/02)
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- Adhesive composition
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An adhesive composition comprises 100 parts by weight of a polymerizable monomer comprising (a) 1.5 to 100 parts by weight of a compound represented by general formula I or II: STR1 where R1 and R1 ' each stand for hydrogen or a methyl group, R2 stands for a divalent organic residue having 4 to 40 carbon atoms, X1 and X2 each stand for --O--, --S-- or --NH--, a is 0 or 1, and R3 stands for a group of the formula STR2 having 6 to 40 carbon atoms, where R4 and R4 ' each stand for a hydrocarbon group having 1 to 29 carbon atoms, and optionally replaced by a halogen atom, or a hydroxyl, amino or carboxyl group, b is an integer of 0 to 3, and Z stands for --O--, --COO-- or --NH--, a plurality of R4 ' (when b is 2 or 3) being the same or different, at least one of R4 and R4 ' having at least three carbon atoms, and (b) 0 to 98.5 parts by weight of a vinyl monomer copolymerizable with the above compound; and 0.01 to 20 parts by weight of a curing agent. It shows a superior adhesive strength on any of hard tissues in a living body, such as teeth and bones, metals, organic polymers and ceramics. It maintains a high adhesive strength for a long time even if it is exposed to moisture, or immersed in water. It is particularly effective for use in dentistry, though it is useful for a variety of other purposes, too.
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