cas 23511-50-4, 2-CHLORO-N-CYCLOHEPTYLACETAMIDE | Articles data ｜lookchem

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23511-50-4

Articles about 23511-50-4Total 2 be found

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Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts
Glucocorticoids form a critical component of chemotherapy regimens for pediatric acute lymphoblastic leukemia (ALL) and the initial response to glucocorticoid therapy is a major prognostic factor, where resistance is predictive of poor outcome. A high-throughput screen identified four thioimidazoline-containing compounds that reversed dexamethasone resistance in an ALL xenograft derived from a chemoresistant pediatric ALL. The lead compound (1) was synergistic when used in combination with the glucocorticoids, dexamethasone or prednisolone. Synergy was observed in a range of dexamethasone-resistant xenografts representative of B-cell precursor ALL (BCP-ALL) and T-cell ALL. We describe here the synthesis of twenty compounds and biological evaluation of thirty two molecules that explore the structure-activity relationships (SAR) of this novel class of glucocorticoid sensitizing compounds. SAR analysis has identified that the most effective dexamethasone sensitizers contain a thioimidazoline acetamide substructure with a large hydrophobic moiety on the acetamide. This journal is
Toscan, Cara E.,Rahimi, Marwa,Bhadbhade, Mohan,Pickford, Russell,McAlpine, Shelli R.,Lock, Richard B.
p. 6299 - 6312
(2015/06/08)

Facile conversion of alcohols into N-substituted amides by magnesium hydrogensulfate under heterogeneous conditions
Different classes of alcohols react efficiently with nitriles in the presence of magnesium hydrogensulfate, Mg(HSO4)2, to produce amides in high yields.
Salehi,Khodaei,Zolfigol,Keyvan
p. 1947 - 1951
(2007/10/03)

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Chemical Properties

Melting Point: 69.5-72.0 °C
Boiling Point: 340.9°C at 760 mmHg
Flash Point:160°C
Density: 1.07g/cm³
Vapor Pressure: 8.31E-05mmHg at 25°C
Refractive Index: 1.483
PKA: 13.97±0.20(Predicted)
PSA: 29.10000
LogP: 2.45510

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