Compounds that degrade BRD9 or MTH1 via the ubiquitin proteasome pathway in a subject in need thereof for therapeutic applications are provided. The compounds provided have an E3 Ubiquitin Ligase targeting moiety (Degron) that is linked to a Targeting Ligand for BRD9 or MTH1.
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(2020/03/29)
Synthesis of new quinoline fused heterocycles such as benzo[h]-1,6- naphthyridines and pyrazolo[4,3 c]quinolines
Synthesis of novel benzo[h]-1,6-naphthyridines was successfully achieved by cyclocondensation of ethyl 4-aminoquinoline-3-carboxylates with malononitrile. The pyrazolo[4,3-c]quinolines were synthesized by nucleophilic substitution and subsequent addition
Ghotekar, Bhausaheb Kedarnath,Ghagare, Maruti G.,Toche, Raghunath B.,Jachak, Madhukar N.
experimental part
p. 169 - 175
(2010/08/05)
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