cas 235114-32-6, Micafungin | Articles data

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INTERMEDIATES AND PROCESSES TO PREPARE MICAFUNGIN
The present invention relates to active esters of compound of Formula I-A and Formula I-B which are used as key intermediates in the synthesis of Micafungin, an antifungal agent and process of preparation of said active esters. The invention also relates to process of preparing Micafungin from said active esters.
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Paragraph 0049

(2016/05/02)

METHODS FOR MANUFACTURING AN ANTIFUNGAL AGENT
The present invention relates to an improved process for the preparation of Micafungin.
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Paragraph 0065

(2015/01/06)

PREPARATION OF MICAFUNGIN INTERMEDIATES
The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, preferably micafungin (MICA) or a salt thereof.
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(2014/11/13)

PREPARATION OF MICAFUNGIN INTERMEDIATES
The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, pr
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Page/Page column 39

(2013/03/26)

Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin
Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound 8 with an excellent, well-balanced profile. Potent compounds with reduced hemolytic potential were designed based upon a disruption of the linearity of the terphenyl lipophilic side chain. The optimized compound (8, FK463, micafungin) displayed the best balance and was selected as the clinical candidate.
Tomishima, Masaki,Ohki, Hidenori,Yamada, Akira,Maki, Katsuyuki,Ikeda, Fumiaki
p. 2886 - 2890
(2008/12/23)

Chemical Properties

Density: 1.62 g/cm³
Solubility:DMSO (Slightly), Methanol (Very Slightly, Heated)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Refractive Index: 1.706
PKA: -4.46±0.18(Predicted)
PSA: 518.52000
LogP: -0.53900

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235114-32-6

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Chemical Properties

Density: 1.62 g/cm³

Solubility:DMSO (Slightly), Methanol (Very Slightly, Heated)

Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere

Refractive Index: 1.706

PKA: -4.46±0.18(Predicted)

PSA: 518.52000

LogP: -0.53900

Global suppliers and manufacturers of 235114-32-6total 116 suppliers on LookChem

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235114-32-6

Articles about 235114-32-6Total 5 be found

More Articles about upstream products of 235114-32-6

Chemical Properties

Density: 1.62 g/cm3

Solubility:DMSO (Slightly), Methanol (Very Slightly, Heated)

Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere

Refractive Index: 1.706

PKA: -4.46±0.18(Predicted)

PSA: 518.52000

LogP: -0.53900

Global suppliers and manufacturers of 235114-32-6total 116 suppliers on LookChem

Density: 1.62 g/cm³