- Anti-Angiogenic Compounds
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Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.
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Paragraph 0137; 0145
(2016/11/24)
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- ANTI-ANGIOGENIC COMPOUNDS
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Compounds of the formula A-X-Y-B and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age- related macular degeneration, diabetic retinopathy or cancer, wherein A is a six membered heteroaryl ring containing 2 nitrogen atoms which is optionally substituted with R1; R1 is H, CI-6 alkyl, CN, CONR2R3; R2 and R3 which may be the same or different and selected from H, CI-6 alkyl or R2 and R3 form a ring; the group X-Y is an alkyne or alkene, in the case wherein X-Y is an alkene the double bond may be cis or trans and optionally substituted with R1 B is an aryl; or five or six membered heteroaryl ring containing 1 to 3 heteroatoms, both of which may optionally substituted with one or more R4; R4 is R1 or OR5; R5 is H, COR6 or R6; and R6 is CI-6 alkyl and salts thereof.
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Page/Page column 20; 21
(2015/08/03)
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- Antiarrhythmic method of use
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Pharmaceutical compositions containing as an active ingredient a compound of the formula STR1 wherein R1 is hydrogen or methyl, Ar is phenyl, 2-pyridyl, 6-methyl-2-pyridyl, 2-quinolyl, 1-methyl-benzimidazol-2-yl, 2-pyrazinyl or 3-methyl-isoxazo
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