Intramolecular cyclization of N-acetyl-6-(cyclopent-1-enyl)-2-methylaniline
N-Acetyl-6-(cyclopent-1-enyl)-2-methylaniline underwent intramolecular cyclization in the presence of HCl in CH2Cl2 at 20 deg C to form 2,8-dimethylspiro[cyclopentane-1,4'-4'H-3,1-benzooxazine] in quantitative yield.
Gataullin, R. R.,Afon'kin, I. S.,Pavlova, I. V.,Abdrakhmanov, I. B.,Tolstikov, G. A.
The first synthesis of benzo[e]cycloalk[g]oxazocinone atropisomers via lactonization of N-mesyl- or N-arylsulfonyl-N-[2-(1-cycloalken-1-yl)-6-methylphenyl]glycines
The article describes an efficient access to cycloalkene-annulated benzoxazocines displaying both axial and central chiralities, via a domino halogenation-lactonization reaction of substituted glycine precursors. Upon interaction between N-[2-(1-cyclohexe
Gataullin, Rail R.
(2021/08/23)
Synthesis of 3,1-benzoxazines from N-substituted ortho-(cycloalk-1-enyl or alk-2-en-2-yl)anilines
New derivatives of 3,1-benzoxazine have been synthesized by the cyclization of RCO-substituted at the nitrogen atom (R = OEt, Me, NH2) ortho-(cycloak-1-enyl or alken-l-yl)anilines under mild conditions.
Gataullin,Afon'kin,Fatykhov,Abdrakhmanov
p. 331 - 335
(2007/10/03)
Synthesis and local anesthetic activity of ortho-(cyclopentenyl)- and ortho-(cyclopentyl)-aniline derivatives
Synthesis of para-cyclopentylanilines from ortho-(cyclopent-1′-enyl)anilines
ortho - para-Migration of the cyclopentenyl fragment in 2-(cyclopent-1′-enyl)aniline or 2-(cyclopent-1′-enyl)-6-methylaniline hydrochloride at 200 °C gives 4-cyclopentylaniline or 4-cyclopentyl-2-methylaniline.