- Preparation method of clotrimazole
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The invention provides a preparation method of clotrimazole. The preparation method comprises the following steps: step 1, chlorinating (2-chlorphenyl) diphenyl methanol into (2-chlorphenyl) diphenylchloromethane; 2, subjecting (2-chlorphenyl) diphenyl chloromethane and imidazole to condensation to form clotrimazole; the total reaction flow formula is shown in the specification. The invention provides a preparation method of clotrimazole. The initial raw materials (2-chlorphenyl) diphenyl methanol and imidazole are easy to obtain and stable in performance; reaction condition mildness, a product which is unstable when meeting water and synthesized in step 1 does not need to be separated and purified, and can be applied directly in step 2, not only are the requirements on equipment and operation reduced, but also the risk of influencing the quality of the raw material medicine is reduced; the preparation method is simple in operation, short in process period, high in product purity andsuitable for industrial production, , in addition, the reaction solvent in the step 1 is also the reaction solvent in the step 2, emission of three wastes is reduced, and environmental protection is better facilitated.
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Paragraph 0027-0029; 0033-0038; 0042-0048
(2020/07/28)
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- Synthesis method of clotrimazole
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The invention discloses a synthesis method of clotrimazole, and belongs to the technical field of chemical synthesis. According to the method, 2-chlorotrityl chloride and imidazole are taken as raw materials, hexafluoroisopropanol is taken as a solvent, and reaction is performed in an alkali environment. The method has the advantages that the raw materials 2-chlorotrityl chloride and imidazole areeasy to get; the reaction can be performed at room temperature, and the reaction condition is mild; other than previous multistep reaction, the method adopts one-step synthesis and is simple to operate; the method is high in reaction activity, the yield reaches 92 percent, and the raw materials are completely converted; products are convenient to separate, and the reaction has green economical efficiency, and is environmentally friendly.
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Paragraph 0020; 0021; 0022; 0023; 0024; 0025; 0026-0076
(2018/03/28)
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- Fluorinated Alcohol-Promoted Reaction of Chlorohydrocarbons with Diverse Nucleophiles for the Synthesis of Triarylmethanes and Tetraarylmethanes
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This article reports an efficient synthesis of triarylmethanes and tetraarylmethanes from chlorohydrocarbons with miscellaneous nucleophiles in fluorinated alcohols, featuring metal-free, wide substrate scope, excellent functional group tolerance, and mild reaction conditions.
- Yu, Liping,Li, Shuai-Shuai,Li, Weina,Yu, Shitao,Liu, Qing,Xiao, Jian
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p. 15277 - 15283
(2019/01/04)
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- Solid Pharmaceutical Preparations Containing Copolymers Based On Polyethers Combined With Poorly Water-Soluble Polymers
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The invention relates to dosage forms which contain preparations of poorly water-soluble substances in a polymer matrix of polyether copolymers, said polyether copolymers being obtained by the radically initiated polymerization of a mixture from 30 to 80% by weight of N-vinyl lactam, 10 to 50% by weight of vinyl acetate and 10 to 50% by weight of a polyether, and at least one poorly water-soluble polymer, the poorly water-soluble substance being present in the polymer matrix as an amorphous substance.
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- Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
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The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction. Moreover, the invention relates to a method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca).
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- Synthesis and antifungal activity of a series of difluorotritylimidazoles
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1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) (15) was selected among a series of mono-, di- and trifluorotrityl-imidazole antifungal agents as the most potent fluorine containing analogue of clotrimazole.
- Bartroli,Alguero,Boncompte,Forn
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p. 832 - 835
(2007/10/02)
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- Process for preparing N-tritylimidazole compounds
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A process for preparing N-tritylimidazole compounds of the formula: STR1 by the reaction between a tritylcarbinol derivative of the formula: STR2 and an imidazole derivative of the formula: STR3 , characterized in that the reaction is effected in the presence of a phosphorus compound of the formula: STR4
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