- Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH4SCN
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A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N-chlorosuccinimide (NCS) was found to be indispensable, and thiourea could greatly promote the reaction.
- Wang, Cancan,Wang, Zhonghao,Wang, Liang,Chen, Qun,He, Mingyang
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supporting information
p. 1081 - 1085
(2016/11/25)
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- Ferric(III) chloride-promoted electrophilic thiocyanation of aromatic and heteroaromatic compounds
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Indoles, oxindoles and aromatic amino compounds undergo smooth thiocyanation with ammonium thiocyanate in the presence of anhydrous FeCl 3 in dichloromethane under mild conditions to afford the corresponding 3-indolyl and 4-aryl thiocyanates, respectively, in high yields with excellent selectivity. The use of ferric chloride makes it quite simple, more convenient and practical. This new method offers several advantages such as high conversions, cleaner reaction profiles, short reaction times, and the use of inexpensive and readily available catalyst. Georg Thieme Verlag Stuttgart.
- Yadav,Reddy,Krishna,Suresh Reddy,Narsaiah
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p. 961 - 964
(2007/10/03)
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