- Per-3,6-anhydro-α-cyclodextrin and Per-3,6-anhydro-β-cyclodextrin
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The synthesis of the per-3,6-anhydro derivatives of α- and β-cyclodextrins (CDs) is described starting from the corresponding per-6-tosylates.These could only be obtained as pure compounds following repeated HPLC under reversed-phase conditions of the cru
- Ashton, Peter R.,Ellwood, Paul,Staton, Ian,Stoddart, J. Fraser
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- The influence of cyclodextrin modification on cellular uptake and transfection efficiency of polyplexes
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Cyclodextrin-modified polycations have been studied widely due to their low cytotoxicity, low immunogenicity and the ability to form inclusion complexes. However, the influence of CD modification on cellular uptake and transfection efficiency of polyplexe
- Li, Wenyu,Chen, Lina,Huang, Zhixiong,Wu, Xiaofei,Zhang, Yuanfeng,Hu, Qiaoling,Wang, Youxiang
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- Novel hybridized SWCNT-PCD: Synthesis and host-guest inclusion for electrical sensing recognition of persistent organic pollutants
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Fabrication of a hybridized single-walled carbon nanotube (SWCNT) device based on novel sensing material mono-6-deoxy-6-(p-aminophenylamino)-β- cyclodextrin (PCD) via a facile approach has been reported for the first time; moreover, the hybridized materia
- Kong, Lingtao,Wang, Jin,Meng, Fanli,Chen, Xing,Jin, Zhen,Li, Mingqiang,Liu, Jinhuai,Huang, Xing-Jiu
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- Preparation of cyclodextrin-modified multi-walled carbon nanotubes through acylamide bond and its application in capturing b-naphthol from wastewater
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Multi-walled carbon nanotubes (MWNTs) were covalently modified with water-soluble b-cyclodextrin (b-CD) through acylamide bond. The products cyclodextrin modified multi-walled carbon nanotubes [MWNTs-CO-NH-(CH 2)2-NH-CD] were charact
- Song, Xiao-Jie,Yang, Fan,Wei, Xian-Wen,Wang, Xian-Biao,She, Chen-Guang
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- Synthesis of a novel β-cyclodextrin-functionalized Fe3O4/BaMoO4:Dy3+magnetic luminescent hybrid nanomaterial and its application as a drug carrier
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Magnetic luminescent hybrid nanoparticles Fe3O4/BaMoO4:Dy3+ (MLHNPs) were successfully synthesized by the co-precipitation method using ethylene glycol. The MLHNPs are functionalized with β-cyclodextrin (CD) using 3-aminopropyl triethoxysilane (APTES). The surface functionalization of nanoparticles and their conjugation have been confirmed via powder XRD, FTIR, HRTEM, and PL analyses. The feasibility of functionalized MLHNPs as nanocarriers for hydrophobic drugs (triazole derivatives) was verified by studying the uptake and release profile using a triazole derivative as a hydrophobic drug. In addition, the photoluminescence spectroscopy results confirmed the optical imaging capability of MLHNPs. The outcomes of loading and release disclose that this system is likely to be a suitable tool as a hydrophobic drug carrier. This journal is
- Phaomei, G.,Sahoo, Anupam,Swain, Sangita K.,Swain, Sukanta K.,Tripathy, S. K.
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- Construction of micelles based on biocompatible pseudo-graft polymers via β-cyclodextrin/cholesterol interaction for protein delivery
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A novel pseudo-graft copolymer was developed for protein delivery, based on the self-assembly of (6-(2-aminoethyl)-amino-6-deoxy)-cyclodextrin (β-CDen)-modified poly(aspartic acid) (PASP-CD) with cholesterol-modified poly(d,l-lactide) (PLA-Chol) by host-g
- Han, Hui,Liu, De-E,Lu, Hongguang,Gu, Wen-Xing,Gao, Hui
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- Magnetic calcined oyster shell functionalized with taurine immobilized on β-cyclodextrin (Fe3O4/COS@β-CD-SO3H NPs) as green and magnetically reusable nanocatalyst for efficient and rapid synthesis of spirooxindoles
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Abstract: Magnetic calcined oyster shell functionalized with taurine immobilized on β-cyclodextrin (Fe3O4/COS@β-CD-SO3H NPs) was prepared as a new stable, long-lived, highly efficient, and exceptional reusable magnetic nan
- Mohammadian, Narges,Akhlaghinia, Batool
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p. 4737 - 4756
(2019/06/04)
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- β-Cyclodextrin modified silica nanoparticles for Nafion based proton exchange membranes with significantly enhanced transport properties
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In the current study, a composite proton exchange membrane (PEM) was prepared by incorporating β-cyclodextrin (β-CD) modified silica nanoparticles (SN-β-CD) into a Nafion matrix. Due to the decoration of β-CD on the SN surface, SN-β-CD possesses excellent
- Jia, Wei,Feng, Kai,Tang, Beibei,Wu, Peiyi
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p. 15607 - 15615
(2015/08/03)
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- Polycationic glycosides
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Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
- Engel, Robert,Ghan, Ishrat,Montenegro, Diego,Thomas, Marie,Klaritch-Vrana, Barbara,Castano, Alejandra,Friedman, Laura,Leb, Jay,Rothman, Leah,Lee, Heidi,Capodiferro, Craig,Ambinder, Daniel,Cere, Eva,Awad, Christopher,Sheikh, Faiza,Rizzo Lee, Jaime,Nisbett, Lisa-Marie,Testani, Erika,Melkonian, Karin
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experimental part
p. 1508 - 1518
(2011/04/24)
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- Zinc bromide-promoted tosylation of alcohols allows efficient temperature-controlled primary hydroxy sulfonylation
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The combination of zinc bromide with tosyl chloride promoted sulfonylation, allowing temperature-controlled regioselective sulfonylation of carbohydrates which possess both primary and secondary hydroxy groups.
- Yamamura, Hatsuo,Kawasaki, Jyumpei,Saito, Hirokazu,Araki, Shuki,Kawai, Masao
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p. 706 - 707
(2007/10/03)
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- Preparation of heptakis(6-O-(p-tosyl))-β-cyclodextrin and heptakis(6-O-(p-tosyl))-2-O-(p-tosyl)-β-cyclodextrin and their conversion to heptakis(3,6-anhydro)-β-cyclodextrin
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Heptakis(6-O-(p-tosyl))-β-cyclodextrin and heptakis(6-O-(p-tosyl))-2-O-(p-tosyl)-β-cyclodextrin were prepared by the reaction of β-cyclodextrin with p-tosyl chloride in pyridine. They were converted to heptakis(3,6-anhydro)-β-cyclodextrin, constituted from alternative (1C4) glucose units.
- Yamamura,Fujita
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p. 2505 - 2508
(2007/10/02)
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- The Kinetic Effects of Water and of Cyclodextrins on Diels-Alder Reactions. Host-Guest Chemistry. Part 18
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The rates of 19 different dienophiles with mostly cyclopentadiene have been measured in a range of solvents.Water, by comparison with methanol, is found to accelerate the cycloadditions by factors ranging from 15-7 680.While there is no simple correlation of the rate enhancement with the hydrophobicity of the substrates, a correlation can be made in the case of acrylates, which show a decreasing rate effect due to water, and with β-cyclodextrin, which is found to lead to inhibition in these and several other cases.Computer analysis of enzyme-like saturation kinetics-observed with some fumarates in the presence of β-cyclodextrin-indicates apparent binding constants for the ternary complex of ca. 102 dm3 mol-1 and catalytic kcat/ko ratios of up to 100.Heptakis-6 piperidino-β-cyclodextrin in the form of its ammonium salt leads to rate retardation in most of the cases investigated; sodium dodecylsulphate also decreases the constants. α-Cyclodextrin generates small effects, rate retardation, or in one case complete inhibition.
- Sangwan, Naresh K.,Schneider, Hans-Joerg
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p. 1223 - 1228
(2007/10/02)
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- Improved Acylation Rates within Cyclodextrin Complexes from Flexible Capping of the Cyclodextrin and from Adjustment of the Substrate Geometry
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The acylation of β-cyclodextrin by bound substrates has been studied as a model for serine acylase enzymes such as chymotrypsin.Molecular model building suggested that previously examined substrates, which had given acylation rates only a few hundred times accelerated over the hydrolysis rates, were not optimal geometrically.In our work the geometry for such processes has been improved by fashioning an "intrusive floor" on the cyclodextrin cavity, leading to improved rates.Greater improvements have come from substrate modification, using substrates based on the cinnamic acid, adamantane, and ferrocene frameworks.The rates correlate well with the geometric predictions from molecular models.The best case leads to an acceleration of acylation, relative to hydrolysis, of 106-107-fold, exceeding that for chymotrypsin with p-nitrophenyl acetate.
- Breslow, Ronald,Czarniecki, Michael F.,Emert, Jack,Hamaguchi, Hiroshi
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p. 762 - 770
(2007/10/02)
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