237435-85-7

Basic information

• Product Name: 3-amino-5-phenylfuran-2-carbonitrile
• Synonyms: 3-amino-5-phenylfuran-2-carbonitrile;2-FURANCARBONITRILE, 3-AMINO-5-PHENYL-
• CAS NO: 237435-85-7
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19402
• Mol File: 237435-85-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-amino-5-phenylfuran-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-5-phenylfuran-2-carbonitrile(237435-85-7)
• EPA Substance Registry System: 3-amino-5-phenylfuran-2-carbonitrile(237435-85-7)

Safety Data

• Hazardous Substances Data: 237435-85-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-amino-5-phenylfuran-2-carbonitrile is utilized as a key building block for the synthesis of biologically active molecules, contributing to the development of new pharmaceuticals. Its presence in the molecular structure of various compounds can enhance their therapeutic properties, making it a crucial component in drug discovery and medicinal chemistry.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-amino-5-phenylfuran-2-carbonitrile is employed as a structural component to modify and improve the pharmacological properties of drug candidates. Its incorporation can lead to the creation of molecules with enhanced efficacy, selectivity, and safety profiles.
Used in Drug Discovery:
3-amino-5-phenylfuran-2-carbonitrile plays a significant role in drug discovery efforts, where it is used to explore and develop novel therapeutic agents. Its unique structural features allow for the design of molecules with potential applications in treating various diseases and conditions.
While the compound's potential extends to other industrial processes and chemical reactions, further research and development are essential to fully understand and exploit its capabilities across different sectors.

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Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacological data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist might be a useful therapeutic agent for the treatment of obesity. In attempts to identify potential Y5 antagonists, a series of pyrrolo[3,2-d]pyrimidine derivatives was prepared and evaluated for their ability to bind to Y5 receptors in vitro. We report here the synthesis and initial structure-activity relationship investigations for this class of compounds. The target compounds were prepared by a variety of synthetic routes designed to modify both the substitution and the heterocyclic core of the pyrrolo[3,2-d]pyrimidine lead 1. In addition to identifying several potent Y5 antagonists for evaluation as potential antiobesity agents, a pharmacophore model for the human Y5 receptor is presented.