23845-96-7

Basic information

• Product Name: 2-BENZYLOXY-PYRIDIN-3-YLAMINE
• Synonyms: 3-AMINO-2-BENZYLOXYPYRIDINE;2-BENZYLOXY-PYRIDIN-3-YLAMINE;2-(Phenylmethoxy)-3-pyridinamine;Pyridine,3-amino-2-(benzyloxy)- (8CI)
• CAS NO: 23845-96-7
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Product Categories: Pyridine;pharmacetical
• Mol File: 23845-96-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-BENZYLOXY-PYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLOXY-PYRIDIN-3-YLAMINE(23845-96-7)
• EPA Substance Registry System: 2-BENZYLOXY-PYRIDIN-3-YLAMINE(23845-96-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 23845-96-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
2-BENZYLOXY-PYRIDIN-3-YLAMINE is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and biologically active molecules. Its unique structure allows for the creation of complex organic molecules with specific therapeutic properties and functions.
Used in Organic Synthesis:
In the field of organic synthesis, 2-BENZYLOXY-PYRIDIN-3-YLAMINE serves as a versatile building block, enabling chemists to construct a wide array of complex organic molecules. Its reactivity and structural features facilitate the synthesis of compounds with tailored properties for various applications.
Used as a Reagent in Chemical Reactions:
2-BENZYLOXY-PYRIDIN-3-YLAMINE can be employed as a reagent in various chemical reactions, aiding in the formation of desired products with specific characteristics. Its role in these reactions is crucial for achieving the desired outcomes in the synthesis of target molecules.

Upstream product

• 111301-96-3 2-(benzyloxy)-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 6298-19-7 2-chloro-3-aminopyridine 
• 1415151-96-0 2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one 

Relevant articles and documents

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES

Compoundshaving the chemical structure of formula (I) are disclosed; as well as process for theirpreparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

PROCESS FOR PRODUCING AROMATIC AMINE HAVING ARALKYLOXY OR HETEROARALKYLOXY GROUP

There is provided a process for producing an aromatic amine compound having an aralkyloxy or heteroaralkyloxy group, in which an aromatic nitro compound having an aralkyloxy or heteroaralkyloxy group is reacted with hydrogen under mild conditions in accordance with a simple procedure while preventing the removal of aralkyl or heteroaralkyl group and keeping stable the other substituents on the aryl group or heteroaryl group so that the substituent does not take part in the reaction, to selectively reduce only the nitro group. The present invention is directed to a process for producing an aromatic amine compound which comprises reacting an aromatic nitro compound represented by the general formula (1): wherein Ar represents an aryl group or heteroaryl group which may have a substituent, and Z represents a divalent aromatic group which may have a substituent, with hydrogen in the presence of a metal catalyst to obtain an aromatic amine compound represented by the general formula (2): wherein Ar and Z have the meaning as defined above.