23956-12-9

Basic information

• Product Name: 5-(2-HYDROXYETHYL)URACIL
• Synonyms: 5-(2-HYDROXYETHYL)URACIL;2,4(1H,3H)-Pyrimidinedione, 5-(2-hydroxyethyl)-;5-(2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione;5-(2-Hydroxyethyl)-2,4(1H,3H)-pyriMidinedione;5-(2-hydroxyethyl)-1H-pyrimidine-2,4-dione;5-(2-Hydroxyethyl)pyrimidine-2,4-diol;NSC 528412;5-(2-Hydroxyethyl)
• CAS NO: 23956-12-9
• Molecular Formula: C₆H₈N₂O₃
• Molecular Weight: 156.14
• Mol File: 23956-12-9.mol

Chemical Properties

• Melting Point: 264-265 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.324 g/cm³
• Refractive Index: 1.52
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.81±0.10(Predicted)
• CAS DataBase Reference: 5-(2-HYDROXYETHYL)URACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXYETHYL)URACIL(23956-12-9)
• EPA Substance Registry System: 5-(2-HYDROXYETHYL)URACIL(23956-12-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23956-12-9(Hazardous Substances Data)

Usage

Uses

Used in Biochemistry Research:
5-(2-Hydroxyethyl)uracil is used as a research reagent for studying the structure, properties, and functions of nucleic acids and their components. Its unique chemical structure allows for the investigation of various biochemical processes and interactions.
Used in Chemical Research:
In the field of chemical research, 5-(2-Hydroxyethyl)uracil serves as a valuable compound for the synthesis of other organic compounds and the development of new chemical reactions. Its hydroxyethyl group at the C5 position provides opportunities for further functionalization and modification, expanding its potential applications in chemical synthesis.
Used in Pharmaceutical Development:
Although not explicitly mentioned in the provided materials, 5-(2-Hydroxyethyl)uracil's unique structure and properties may also make it a candidate for pharmaceutical development. Its potential use in the design and synthesis of new drugs targeting specific biological pathways or receptors could be explored in the future.
Used in Material Science:
The stability and chemical properties of 5-(2-Hydroxyethyl)uracil may also find applications in material science, particularly in the development of new materials with unique properties. Its potential use in the synthesis of polymers, coatings, or other materials with specific characteristics could be investigated.

InChI:InChI=1/C6H8N2O3/c9-2-1-4-3-7-6(11)8-5(4)10/h3,9H,1-2H2,(H2,7,8,10,11)

Upstream product

• 89532-90-1 α-(1-carbamyliminomethylene)-γ-butyrolactone 
• 51270-64-5 sodium salt of (Z)-3-(hydroxymethylene)dihydro-2(3H)-furanone 
• 57-13-6 urea 
• 89532-90-1 [2-Oxo-dihydro-furan-(3Z)-ylidenemethyl]-urea 

Downstream Products

• 221170-25-8 5-(β-Amino-ethyl)-uracil 
• 1450618-12-8 5-(2-hydroxyethyl)-N-1-[(1,3-dibenzyloxy-2-propoxy)methyl]pyrimidin-2,4-dione 
• 1450618-13-9 5-(2-chloroethyl)-N-1-[(1,3-dibenzyloxy-2-propoxy)methyl]pyrimidin-2,4-dione 
• 1450618-09-3 5-(2-acetoxyethyl)-N-1-[(1,3-dibenzyloxy-2-propoxy)methyl]pyrimidin-2,4-dione 
• 97974-93-1 1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-(2-hydroxyethyl)-1H,3H-pyrimidine-2,4-dione 
• 108008-62-4 1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-(2-hydroxy-ethyl)-1H-pyrimidine-2,4-dione 
• 90301-63-6 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-69-2 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 53438-96-3 5-(2-bromoethyl)uracil 
• 90301-59-0 5-(2-chloroethyl)-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 158226-24-5 α-5-(bromoethynyl)-1-<2-'deoxy-3',5'-di-O-(p-chlorobenzoyl)>-uridine 
• 158226-23-4 β-5-(bromoethynyl)-1-<2-'deoxy-3',5'-di-O-(p-chlorobenzoyl)>-uridine 
• 80384-36-7 5-(bromoethynyl)-β-2'-deoxyuridine 
• 80384-36-7 5-(bromoethynyl)-α-2'-deoxyuridine 

Relevant articles and documents

Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives

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Synthesis and structural characterization of the 5-(2-haloethyl)pyrimidines - hydrogen-bonded chains in α-(1-carbamyliminomethylene)-γ- butyrolactone

Three novel 5-(2-haloethyl)pyrimidine derivatives were synthesized and characterized by 1H-NMR, 13C-NMR, MS, IR spectra and elemental analysis. Iodine and chlorine atoms in the C-5 side chain were introduced by reaction of 5-(2-hydro

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