239810-43-6

Basic information

• Product Name: 2,6-DICHLORO-PYRIDINE-3-SULFONYL CHLORIDE
• Synonyms: 2,6-DICHLORO-PYRIDINE-3-SULFONYL CHLORIDE;3-Pyridinesulfonyl chloride, 2,6-dichloro-;2,6-Dichloro-3-Pyridinesulfonyl chloride;2,6-Dichloro-pyridine-3-sulphonylchloride
• CAS NO: 239810-43-6
• Molecular Formula: C5H2Cl3NO2S
• Molecular Weight: 246.5
• Mol File: 239810-43-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-DICHLORO-PYRIDINE-3-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-PYRIDINE-3-SULFONYL CHLORIDE(239810-43-6)
• EPA Substance Registry System: 2,6-DICHLORO-PYRIDINE-3-SULFONYL CHLORIDE(239810-43-6)

Safety Data

• Hazardous Substances Data: 239810-43-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,6-Dichloro-pyridine-3-sulfonyl chloride is used as an intermediate or reagent in the production of various chemical products. Its unique structure, featuring chloro and sulfonyl functional groups on a pyridine ring, makes it a valuable component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,6-Dichloro-pyridine-3-sulfonyl chloride is used as a key building block in the synthesis of certain drugs. Its reactivity and functional groups enable the creation of complex molecular structures that can be further utilized in the development of new medications.
Used in Chemical Research:
2,6-Dichloro-pyridine-3-sulfonyl chloride is also employed in chemical research as a model compound for studying the properties and reactions of chloro and sulfonyl groups. This helps researchers gain a deeper understanding of the underlying chemical mechanisms and potentially discover new applications for this versatile reagent.

Upstream product

• 62476-56-6 3-amino-2,6-dichloropyridine 

Downstream Products

• 1450621-30-3 2-(4-(4-((6-amino-2-chloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450621-29-0 2-(4-(4-((6-amino-2-(methylamino)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450621-32-5 2-(4-(4-((6-amino-2-methoxy-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450621-33-6 2-(4-(4-((6-amino-2-(benzyloxy)-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1450621-34-7 2-(4-(4-((6-amino-2-methyl-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 
• 1361221-60-4 2-(4-(4-((2,6-dichloro-3-pyridinyl)sulfonyl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 

Relevant articles and documents

SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to sulfonyl compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

Aqueous process chemistry: The preparation of aryl sulfonyl chlorides

The use of aqueous acidic conditions for the preparation of arylsulfonyl chlorides from diazonium salts in the presence of copper salts, preferably CuCl, together with thionyl chloride as the sulfur dioxide source, has considerable advantages over recommended literature procedures, whereby reactions are carried out in acetic acid with minimisation of water content of the solvent. The method has been shown to be successful for a wide range of electron-deficient and electron-neutral aryl substrates. The sulfonyl chlorides are protected from hydrolysis by their low solubility in water, which results in their direct precipitation from the reaction mixture in good yields (>70%) and high strength (>98% w/w). The aqueous process, which is additionally safer and more robust, can be readily scaled up and has significant environmental benefits.