- 4 - Phenyl - 2 - amino pyrimidine compound and its preparation method and application
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The invention discloses a 4-phenyl-2-aminopyrimidine compound, the structure of which is shown in the general formula I, wherein X is shown in the specification, R0 is hydrogen, methyl or ethyl; R1 is hydrogen, methyl, ethyl or isopropyl; R2 is isopropyl,
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Paragraph 0054-0055
(2018/03/24)
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- Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop
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We report the synthesis of two new artificial nucleobase scaffolds, 1 and 2, featuring adequate hydrogen bonding donors and acceptors for the molecular recognition of U:A and C:G base pairs, respectively. The tethering of these structures to various amino acids and the assessment of these artificial nucleobase-amino acid conjugates as RNA ligands against a model of HCV IRES IIId domain are also reported. Compound 1e displayed the highest affinity (Kd twice lower than neomycin – control). Moreover, it appears that this interaction is enthalpically and entropically favored.
- Safir Filho, Mauro,Martin, Anthony R.,Benhida, Rachid
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p. 1780 - 1783
(2017/04/03)
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- COMPOUNDS
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A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Anima
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Page/Page column 56
(2017/03/14)
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