- Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors
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1,4,5,6-Tetrahydropyridazine derivative 15 and its C-5 epimer 19, which possessed side chains similar to GS4071, were synthesized via a hetero Diels- Alder reaction, and evaluated as influenza neuraminidase inhibitors. Compounds 15 and 19 exhibited a μM range of influenza neuraminidase inhibitory activity.
- Zhang, Lijun,Williams, Matthew A.,Mendel, Dirk B.,Escarpe, Paul A.,Chen, Xiaowu,Wang, Ke-Yu,Graves, Bradford J.,Lawton, Geoff,Kim, Choung U.
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p. 1751 - 1756
(2007/10/03)
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