- FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same. The present invention also relates to compounds and methods useful for binding and modulating the activity of cereblon (CRBN), especially for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
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Paragraph 00395
(2021/02/12)
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- 1. 3 - Benzoxazine - 2, 4 (3 H) - dione derivatives and their synthesis and use (by machine translation)
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The invention relates to a acetylcholine esterase with phosphodiesterase V enzyme inhibition benzoxazine dione derivative and its synthetic method and use, and in particular relates to the structure of the general formula (I) of 1, 3 benzoxazine - 2, 4 (3 H) - dione derivatives, R1 , R2 , R3 , R4 , R5 , R6 , R7 , R8 And R9 The specification of the existing limited to. This invention refers to these compound structure and synthetic method and in vitro acetylcholine esterase with phosphodiesterase V inhibiting activity, can be further developed into new drugs for treating Alzheimer's disease. (by machine translation)
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- BICYCLIC COMPOUNDS HAVING ACTIVITY AT THE CXCR4 RECEPTOR
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A compound represented by the structural formula (I): Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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Page/Page column 69
(2009/12/27)
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- Synthesis of 2H-1,3-Benzoxazine-2,4(3H)-diones and 2H-Naphth-1,3-oxazine-2,4(3H)-diones
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2H-1,3-Benzoxazine-2,4(3H)-diones and 2H-naphth-1,3-oxazine-2,4(3H)-diones have been synthesized by the reaction of hydroxy aromatic acid chlorides and chlorosulphonyl isocyanate in the presence of triethylamine.
- Dhar, D. N.,Bag, A. K.
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p. 366 - 367
(2007/10/02)
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