Indium-Catalyzed Barbier Reactions of Amino Aldehydes
The indium-catalyzed Barbier-type reaction of Cbz-protected amino aldehydes with methyl 2-(bromomethyl)acrylate in the presence of aluminum or manganese/Me3SiCl was investigated. Best results were obtained using 0.15 equiv. InCl3 wit
Steurer, Steffen,Podlech, Joachim
p. 251 - 254
(2007/10/03)
Aminoalkyl-substituted α-methylene-γ-butyrolactones from α-amino acids using an indium-mediated Barbier allyl addition
The indium-mediated reaction of Z-protected α-amino aldehydes 1-6 with 2-(bromomethyl)acrylates 8/9 in aqueous solvents has been investigated. The preference for the formation of syn-configured homoallyl alcohols 10-16 (diastereoselectivities ranging from
Steurer, Steffen,Podlech, Joachim
p. 1551 - 1560
(2007/10/03)
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