Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent gram-positive and gram-negative antibacterial agents
3,6-Ketals of 15-membered azalide pseudoaglycones are a novel series of macrolide antibiotics. The aromatic derivatives of the azalide 3,6-ketals demonstrated potent antibacterial activities against both Gram-positive and Gram-negative bacteria.
Cheng, Hengmiao,Dirlam, John P.,Ziegler, Carl B.,Lundy, Kristin M.,Hayashi, Shigeru F.,Kamicker, Barbara J.,Dutra, Jason K.,Daniel, Kirsten L.,Santoro, Sheryl L.,George, David M.,Bertsche, Camilla D.,Sakya, Subas M.,Suarez-Contreras, Melani
Azalide 3,6-ketals: Antibacterial activity and structure-activity relationships of aryl and hetero aryl substituted analogues
Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity against veterinary pathogens, including Staphylococcus aureus and Pasteurella multocida.
Sakya, Subas M.,Bertinato, Peter,Pratt, Bryan,Suarez-Contreras, Melani,Lundy, Kristin M.,Minich, Martha L.,Cheng, Hengmiao,Ziegler, Carl B.,Kamicker, Barbara J.,Hayashi, Shigeru F.,Santoro, Sheryl L.,George, David M.,Bertsche, Camilla D.
p. 1373 - 1375
(2007/10/03)
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