- Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
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Drug-induced acute kidney injury (AKI) with a high morbidity and mortality is poorly diagnosed in hospitals and deficiently evaluated in drug discovery. Here, we report the development of molecular renal probes (MRPs) with high renal clearance efficiency
- Huang, Jiaguo,Li, Jingchao,Lyu, Yan,Miao, Qingqing,Pu, Kanyi
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- Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases
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Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is of great importance. However, current available analytical methods neither achieve the real-time monitoring nor provide dynamic information during th
- Chen, Chao,Ding, Dan,Gao, Heqi,Kwok, Ryan T. K.,Ou, Hanlin,Tang, Youhong,Zheng, Donghui
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supporting information
(2022/02/01)
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- MOLECULAR RENAL PROBES FOR DETECTING ACUTE KIDNEY INJURY
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Disclosed herein are compounds or salts and/or solvates of formula I, II and III, where the compounds or salts and/or solvates have the following structures: (X)a-Y-(Z)b I; II; or X'-Y' III; where X, Y, Z, X', Y', a, b, R4
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Page/Page column 89
(2020/08/22)
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- A novel chemiluminescent probe for hydrazine detection in water and HeLa cells
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Hydrazine is a substance harmful to humans and the environment, necessitating the development of a sensitive and specific detection method. Herein, a novel chemiluminescent probe based on Schaap's adamantylidene-dioxetane (CL-HZ) for detecting hydrazine w
- Liu, Jiang,Jiang, Jianze,Dou, Yandong,Zhang, Fangfang,Liu, Xin,Qu, Jiaojiao,Zhu, Qing
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supporting information
p. 6975 - 6979
(2019/08/01)
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- Phosphorylated Polyacrylonitrile Fibers as an Efficient and Greener Acetalization Catalyst
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A novel solid acid catalyst (PANEAPF) is developed by immobilization of phosphoric acid on polyacrylonitrile fiber through covalent bonding. Various characterization techniques such as elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), etc. are utilized to confirm the successful grafting and the stability of the fiber catalysts during application. PANEAPF shows high catalytic activity in the acetalization of aldehydes owing to the high utilization efficiency of its functionalized acid sites. In addition, the strong polarity micro-environment in the surface layers of PANEAPF make it highly suitable for catalytic application in both water and alcohol. Furthermore, the fiber catalyst can be applied to the acetalization of aldehydes in a continuous-flow process at room temperature, and shows excellent reactivity and superior recyclability (over 20 times). The many advantages of PANEAPF such as simple preparation, convenient regulation of acid amount, high durability, and eco-friendly process make it very attractive for fixed-bed reactors in the chemical industry.
- Xu, Gang,Cao, Jian,Zhao, Yali,Zheng, Lishuo,Tao, Minli,Zhang, Wenqin
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supporting information
p. 2565 - 2575
(2017/09/25)
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- Mesoporous sulfated zirconia mediated acetalization reactions
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A novel, convenient, one step synthetic procedure for the synthesis of mesoporous sulfated zirconia (m-SZ) using zirconium carbonate complex and its use as solid acid catalyst for the acetalization of different carbonyl compound is reported. The high specific BET surface area (234 m2 g -1) of m-SZ is achieved after the removal of the surfactant (cetyltrymethylammonium bromide, CTAB) through calcination at 550 °C for 6 h. Microscopic analysis indicated the presence of spherical particles with worm like pores. DRIFT (diffuse reflectance FTIR) of pyridine adsorbed m-SZ and NH3-TPD (temperature programmed desorption) analysis suggested the presence of appreciable amount of Bro?nsted acid sites. The synthesized m-SZ showed high catalytic activity towards protection of carbonyl compounds through acetal/ketal formation. For the open ketal (from cyclohexanone and methanol) 97% conversion with 100% selectivity was obtained in 1 h at room temperature under solvent free condition. The catalyst can be easily recycled after separation from the reaction system without considerable loss in catalytic activity.
- Sinhamahapatra, Apurba,Sutradhar, Narottom,Ghosh, Malay,Bajaj, Hari C.,Panda, Asit B.
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experimental part
p. 87 - 93
(2012/04/10)
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- Tetrabutylammonium tribromide (TBATB) as an efficient generator of HBr for an efficient chemoselective reagent for acetalization of carbonyl compounds
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Acyclic and cyclic acetals of various carbonyl compounds were obtained in excellent yields under a mild reaction condition in the presence of trialkyl orthoformate and a catalytic amount of tetrabutylammonium tribromide (TBATB) in absolute alcohol. Chemoselective acetalization of an aldehyde in the presence of ketone, unsymmetrical acetal formation, shorter reaction times, mild reaction conditions, the stability of acid-sensitive protecting groups, high efficiencies, facile isolation of the desired products, and the catalytic nature of the reagent make the present methodology a practical alternative.
- Gopinath, Rangam,Haque, Sk. Jiaul,Patel, Bhisma K.
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p. 5842 - 5845
(2007/10/03)
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- SUBSTITUTED 4-PHENOXY OR 4-PHENYLTHIO PROLINES
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This invention is directed to substituted 4-phenoxy and 4-phenylthio prolines of the formula STR1 which possess useful hypotensive activity.
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