244122-41-6

Basic information

• Product Name: 5-Cyclohexyloxy-1 H-indole
• Synonyms: 5-Cyclohexyloxy-1 H-indole
• CAS NO: 244122-41-6
• Molecular Formula: C₁₄H₁₇NO
• Molecular Weight: 215.29
• Mol File: 244122-41-6.mol

Chemical Properties

• Boiling Point: 383.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• PKA: 16.63±0.30(Predicted)
• CAS DataBase Reference: 5-Cyclohexyloxy-1 H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Cyclohexyloxy-1 H-indole(244122-41-6)
• EPA Substance Registry System: 5-Cyclohexyloxy-1 H-indole(244122-41-6)

Safety Data

• Hazardous Substances Data: 244122-41-6(Hazardous Substances Data)

Upstream product

• 1953-54-4 indol-5-ol 

Downstream Products

• 1097701-61-5 (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-cyclohexyloxy-1H-indole 
• 301856-43-9 5-cyclohexyloxy-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole 
• 244122-54-1 (R)-5-Cyclohexyloxy-1-(3,4-methylenedioxybenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole 
• 244122-55-2 (R)-5-Cyclohexyloxy-1-(2,6-dichlorobenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole 
• 244122-51-8 (R)-1-(2-Chlorobenzoyl)-5-cyclohexyloxy-3-(1-methyl-2-pyrrolidinylmethyl)indole 
• 244122-72-3 (R)-5-Cyclohexyloxy-3-(1-methyl-2-pyrrolidinylmethyl)-1-(4-methylphenylsulfonyl)indole 
• 244122-52-9 (R)-5-Cyclohexyloxy-1-(2-methoxybenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole 
• 244122-53-0 (R)-5-Cyclohexyloxy-1-(4-methoxybenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole 
• 244122-56-3 (R)-5-Cyclohexyloxy-3-(1-methyl-2-pyrrolidinylmethyl)-1-(2-thienoyl)indole 
• 244122-43-8 (R)-5-cyclohexyloxy-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole 

Relevant articles and documents

Piperidine-indole compounds having 5-HT6 affinity

Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula: wherein: R1 is selected from the group consisting of H and C1-4alkyl; R2 is selected from the group consisting of H, C1-4alkyl and benzyl; - - - represents a single or double bond; R3 is selected from the group consisting of COR5 and SO2R5; R4a is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4b is selected from the group consisting of H, hydroxy, halo, C3-7cycloalkyloxy, C1-4alkoxy, C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R4c is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; R4d is selected from the group consisting of H, OH, halo, C1-4alkyl and C1-4alkoxy; and R5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C1-4alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.

Pyrrolidine-indole compounds having 5-HT6 affinity

Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula: STR1 wherein: R 1 is selected from the group consisting of H and C 1-4 alkyl;R 2 is selected from the group consisting of H, C 1-4 alkyl and benzyl;R 3 is selected from the group consisting of COR 5, SO 2 R 5, CONHC 1-4 alkyl and C(S)SR 6 ;R 4a is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy;R 4b is selected from the group consisting of H, hydroxy, halo, C 3-7 cycloalkyloxy, C 1-4 alkoxy, C 1-4 alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl;R 4c is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy;R 4d is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy;R 5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C 1-4 alkoxy, C 1-4 alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl and C 1-4 alkylS--; andR 6 is selected from C 1-4 alkyl, allyl, propargyl and optionally substituted benzyl wherein the benzyl group is optionally substituted with 1-4 substituents selected from cyano, C 1-4 alkyl and halo.Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT 6 receptor is implicated, such as schizophrenia.