244272-25-1

Basic information

• Product Name: 3-(4-methylphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole
• Synonyms: 3-(4-methylphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole
• CAS NO: 244272-25-1
• Molecular Formula: C14H17N3O
• Molecular Weight: 243.30428
• Mol File: 244272-25-1.mol

Chemical Properties

• Boiling Point: 401.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.118±0.06 g/cm3(Predicted)
• PKA: 9.56±0.10(Predicted)
• CAS DataBase Reference: 3-(4-methylphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole(244272-25-1)
• EPA Substance Registry System: 3-(4-methylphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole(244272-25-1)

Safety Data

• Hazardous Substances Data: 244272-25-1(Hazardous Substances Data)

Upstream product

• 19227-13-5 p-toluamidoxime 
• 263383-21-7 tert-butyl-4-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxylate 
• 104-85-8 para-methylbenzonitrile 
• 1126-09-6 4-carbethoxypiperidine 

Relevant articles and documents

The first one-pot ambient-temperature synthesis of 1,2,4-oxadiazoles from amidoximes and carboxylic acid esters

The first one-pot room-temperature protocol for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles via the condensation between amidoximes and carboxylic acid esters in superbase medium MOH/DMSO is reported. A broad spectrum of alkyl, aryl and hetaryl amidoximes and esters was examined. This reaction route provides convenient access to 1,2,4-oxadiazoles, which is highly desirable because in the light of this privileged scaffold is recognized as an important core in the design of novel therapeutic agents and high-tech materials.

Discovery of highly potent triazole antifungal agents with piperidine-oxadiazole side chains

Due to increasing incidence and mortality of invasive fungal infections, discovery and development of new generations of antifungal agents represents a challenging task. On the basis of our previously reported triazole-benzyloxypiperidinyl lead compound, a series of novel triazole antifungal agents containing piperidine-oxadiazole side chains were rationally designed and synthesized. Most of the target compounds showed excellent inhibitory activity against clinically important fungal pathogens. In particular, compounds 6g (MIC = 0.031 μg mL-1) and 11b (MIC = 0.016 μg mL-1) were highly active against Candida albicans including fluconazole-resistant strains. Moreover, they showed inhibitory activity against hyphal formation with low toxicity, which were promising leads for further development. This journal is

COMPOUNDS HAVING AN ETHR INHIBITING ACTIVITY - USE OF SAID COMPOUNDS AS DRUGS - PHARMACEUTICAL COMPOSITION AND PRODUCT CONTAINING SAID COMPOUNDS

The present invention relates to compounds of Formula (I), wherein R1 is chosen among the following radicals : (II); (III); (IV), (V), (VI) (VII) and n= 1 or 2 and m=1 or 2 with the proviso that m=2 when R1 is (VIII). The present invention also relates to the use thereof as drugs, more particularly in the treatment of mycobacterial infections and more particularly in the treatment of tuberculosis.