Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light
Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.
Ozaki, Tomoya,Yorimitsu, Hideki,Perry, Gregory J. P.
p. 15387 - 15391
(2021/10/04)
A general copper-catalyzed sulfonylation of arylboronic acids
A general copper-catalyzed method for the sulfonylation of arylboronic acids with sulfinate salts is described. A variety of alkyl-aryl, diaryl, and alkyl-heteroaryl sulfones were synthesized in good yield.
Kar, Anirban,Sayyed, Lliyas Ali,Lo, Wei Fun,Kaiser, Hanns Martin,Beller, Matthias,Tse, Man Kin
p. 3405 - 3408
(2008/02/12)
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