- Preparation method of 3-carboxymethyl-1,2,4-cyclopentanetricarboxylic acid-1,4:2,3-dianhydride
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The invention discloses a preparation method of 3-carboxymethyl-1,2,4-cyclopentanetricarboxylic acid-1,4:2,3-dianhydride and belongs to the field of preparation methods of fine chemicals. The main technical scheme is that dicyclopentadiene is taken as a starting material and subjected to oxidation reaction with ozone and hydrogen peroxide sequentially, intermediate product 2,3,5-tricarboxylic acidcyclopentane acetic acid is obtained, finally, acetic anhydride is taken as a dehydrating agent, and dehydration ring closing is performed for synthesizing the target product 3-carboxymethyl-1,2,4-cyclopentanetricarboxylic acid-1,4:2,3-dianhydride. The method in the scheme has the advantages of being mild in reaction condition, safe to operate, high in product purity and yield, pollution-free andthe like, and is suitable for large-scale industrial production.
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Paragraph 0018; 0020; 0022; 0024; 0026; 0028; 0030; 0032;
(2019/04/04)
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- A 2, 3, 5-three carboxyl cyclopentyl process for the preparation of acetic acid
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The invention discloses a method for preparing 2,3,5-tricarboxyl cyclopentylacetic acid. The method comprises the following steps: step 1, dissolving dicyclopentadiene in a mixed solvent of tetrahydrofuran and water; step 2, adding osmium tetroxide in a catalytic amount; step 3, adding sodium periodate; step 4, stirring for a certain time; step 5, pouring the mixture into water, and filtering; step 6, adding solids into a mixed solvent of an organic solvent and water; step 7, stirring, adding hydrogen peroxide, slowly heating to a certain temperature, and adding hydrogen peroxide in batches; step 8, stirring for a certain time; and step 9, distilling to obtain transparent viscous fluid, wherein a weight ratio of tetrahydrofuran to water in the step 1 is 1:1-10:1, a weight ratio of the mixed solvent to dicyclopentadiene is 40:1-100:1, and a weight ratio of osmium tetroxide to dicyclopentadiene is 1:500. The method for preparing the 2,3,5-tricarboxyl cyclopentylacetic acid disclosed by the invention is high in reaction speed and high in product purity and is suitable for large-scale industrial production.
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Paragraph 0059; 0060
(2017/09/19)
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