- ANTIVIRAL COMPOUNDS
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The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.
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Paragraph 0944; 0945
(2018/04/13)
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- 2-PYRROLIDONE SUBSTITUTED DIHYDROXY ALKANOIC, ALKENOIC AND ALKYNOIC ACIDS, COMPOSITIONS AND HMG-COA REDUCTASE INHIBITION THEREWITH
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Antihypercholesterolemic activity has been discovered in compounds of the formula and pharmaceutically acceptable salts thereof, wherein: Z is X is lower alkyl, lower alkenyl, or lower alkenyl; R1 is hydrogen, alkyl, alkenyl, aryl, alkylaryl, or substituted aryl having one or more substituents; and one of R2 and R3 is hydrogen and the other is hydrogen, alkyl, alkenyl, aryl, alkylaryl or alkenyl aryl; or R2 and R3 are both lower alkyl; or R2 and R3 together complete a substituted or unsubstituted hydrocarbon ring that is cycloalkyl or cycloalkenyl with substituents as defined in the specification.
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- 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
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Antihypercholesterolemic activity is exhibited by novel compounds of the formula STR1 wherein: Z is STR2 X is lower alkyl or lower alenyl; R1 is aryl or alkyl; R2 and R3 are the same or different and are hydrogen, or lower
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