- TYK2 INHIBITORS AND USES THEREOF
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Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
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Paragraph 00611
(2020/06/10)
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- Structure-based design of a non-peptidic antagonist of the SH2 domain of Grb2
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The structure-based design and synthesis of a completely non-peptidic, micromolar antagonist of the SH2 domain of Grb2 is presented. The compound mimics the two main pharmacophores of the natural ligand, the phenylphosphate of the phosphotyrosine residue and the β-carboxamide of the X+2 asparagine, which are linked by a rigid aromatic spacer.
- Caravatti, Giorgio,Rahuel, Joseph,Brigitte, Gay,Furet, Pascal
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p. 1973 - 1978
(2007/10/03)
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