- Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
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Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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- METHODS FOR TREATING COGNITIVE DISORDERS USING 1-ARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 1-HETEROARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES AND RELATED COMPOUNDS
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Disclosed herein are methods of treating a patient suffering from a cognitive disorder using compounds of the following formula, Formula (2), wherein the variables have the meaning defined in the specification.
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Page/Page column 41-42
(2008/12/08)
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- METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
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Disclosed herein are methods of treating a patient suffering from a cognitive disorder using the following compounds (I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII).
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Page/Page column 22-23
(2008/12/08)
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- METHODS FOR TREATING CHRONIC PAIN USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES,3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
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Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds:
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Page/Page column 38-39
(2010/11/29)
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- METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS
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The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.
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Page/Page column 27-28
(2008/06/13)
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- syn-selective additions to Garner aldehyde: Synthesis of a potent glucosylceramide synthase inhibitor
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Highly syn-selective additions of aryl Grignard reagents to Garner aldehyde 5 are reported, making possible a practical, asymmetric synthesis of the potent glucosylceramide synthase inhibitor 3.
- Husain, Arifa,Ganem, Bruce
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p. 8621 - 8623
(2007/10/03)
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