245653-50-3

Basic information

• Product Name: 4-chloro-2-methyl-1-indanone
• Synonyms: 4-chloro-2-methyl-1-indanone;4-chloro-2-Methyl-2,3-dihydro-1H-inden-1-one;4-chloro-2,3-dihydro-2-Methyl-1H-Inden-1-one
• CAS NO: 245653-50-3
• Molecular Formula: C10H9ClO
• Molecular Weight: 181
• EINECS: 1533716-785-6
• Mol File: 245653-50-3.mol

Chemical Properties

• Boiling Point: 288.6 °C at 760 mmHg
• Flash Point: 139.1 °C
• Appearance: /
• Density: 1.229 g/cm³
• Vapor Pressure: 0.00231mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-chloro-2-methyl-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-methyl-1-indanone(245653-50-3)
• EPA Substance Registry System: 4-chloro-2-methyl-1-indanone(245653-50-3)

Safety Data

• Hazardous Substances Data: 245653-50-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-chloro-2-methyl-1-indanone is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications and improving existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 4-chloro-2-methyl-1-indanone is utilized as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Fine Chemicals Production:
4-chloro-2-methyl-1-indanone is employed as a building block in the manufacture of fine chemicals, which are high-purity chemicals used in various applications, including research, pharmaceuticals, and other specialized industries.
Used in Active Pharmaceutical Ingredients (API) Synthesis:
4-chloro-2-methyl-1-indanone is used as a key component in the synthesis of active pharmaceutical ingredients, playing a crucial role in the development of effective and safe medications.

InChI:InChI=1/C10H9ClO/c1-6-5-8-7(10(6)12)3-2-4-9(8)11/h2-4,6H,5H2,1H3

Upstream product

• 880653-64-5 3-(2-chlorophenyl)-2-methylpropanoyl chloride 

Relevant articles and documents

Halogen substituted metallocene compounds for olefin polymerization

A metallocene compound is represented by the formula (1): wherein: M is a Group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom, preferably a Group 4 transition metal atom selected from titanium, zirconium or hafnium; E is a substituted or unsubstituted monocyclic or polycyclic arenyl ligand pi-bonded to M; A is a substituted or unsubstituted polycyclic arenyl ligand that is pi-bonded to M and has a different ring structure than the E ligand; at least one of the A and E ligands includes at least one halogen substituent directly bonded to an sp2 carbon at a bondable ring position; Y is a bridging group containing at least one Group 13, 14, 15, or 16 element and any single position of the ring structure of A and to any single position of the ring structure of E; and y is zero or 1, indicating the absence (y=0) or presence (y=1) of Y; and each X is a univalent anionic ligand, or two X are joined and bound to the metal atom to form a metallocycle ring, or two X are joined to form a chelating ligand, a diene ligand, or an alkylidene ligand; provided that when E is an unsubstituted cyclopentadienyl ligand, either y is one or A is not 2-bromofluorenyl or 2,7-dibromofluorenyl.

Preparation of substituted bridged indenyl and related ligands

A process for preparing a chelating ligand of the formula (II) from a chelating ligand of the formula (I) via an sp2-sp2 or sp2-sp3 coupling reaction with an organometallic compound of the formula (III). wherein

HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION

A metallocene compound is represented by the formula (1): wherein: M is a Group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom, preferably a Group 4 transition metal atom selected from titanium, zirconium or hafnium; E is a substituted or unsubstituted monocyclic or polycyclic arenyl ligand pi-bonded to M; A is a substituted or unsubstituted polycyclic arenyl ligand that is pi-bonded to M and has a different ring structure than the E ligand; at least one of the A and E ligands includes at least one halogen substituent directly bonded to an sp2 carbon at a bondable ring position; Y is a bridging group containing at least one Group 13, 14, 15, or 16 element and any single position of the ring structure of A and to any single position of the ring structure of E; and y is zero or 1, indicating the absence (y = 0) or presence (y =1) of Y; and each X is a univalent anionic ligand, or two X are joined and bound to the metal atom to form a metallocycle ring, or two X are joined to form a chelating ligand, a diene ligand, or an alkylidene ligand; provided that when E is an unsubstituted cyclopentadienyl ligand, either y is one or A is not 2-bromofluorenyl or 2,7-dibromofluorenyl.

Preparation of preparing substituted indanones

a process for the preparation of indanones of the formula II from, indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling component.