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245728-73-8

2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE is a chemical compound with the molecular formula C12H13NO3. It belongs to the class of isoindole-1,3(2H)-dione derivatives, which are known for their potential pharmacological properties and use in the synthesis of pharmaceuticals. This specific compound features a hydroxyl group and a methyl group attached to a chiral carbon, endowing it with stereochemical properties. Its potential applications in the pharmaceutical industry include drug development and as a research tool in biological studies. Further research is necessary to explore its specific uses and effects.

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  • 245728-73-8 Structure

  • Basic information

    1. Product Name: 2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE
    2. Synonyms: (S)-2-(4-hydroxybutan-2-yl)isoindoline-1,3-dione;2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE
    3. CAS NO:245728-73-8
    4. Molecular Formula: C12H13NO3
    5. Molecular Weight: 219.23652
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 245728-73-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 378.215 °C at 760 mmHg
    3. Flash Point: 182.538 °C
    4. Appearance: /
    5. Density: 1.3 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 14.90±0.10(Predicted)
    10. CAS DataBase Reference: 2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE(245728-73-8)
    12. EPA Substance Registry System: 2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE(245728-73-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 245728-73-8(Hazardous Substances Data)

245728-73-8 Usage

Uses

Used in Pharmaceutical Industry:
2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE is used as a chemical intermediate for the synthesis of pharmaceuticals due to its unique structure and potential pharmacological properties.
Used in Drug Development:
2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE serves as a promising candidate in drug development, as its stereochemistry and functional groups may contribute to the design of novel therapeutic agents with specific biological activities.
Used in Biological Research:
2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE is utilized as a research tool in biological studies to investigate its interactions with biological targets and explore its potential as a lead compound for the development of new drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 245728-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,5,7,2 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 245728-73:
(8*2)+(7*4)+(6*5)+(5*7)+(4*2)+(3*8)+(2*7)+(1*3)=158
158 % 10 = 8
So 245728-73-8 is a valid CAS Registry Number.

245728-73-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(1R)-3-HYDROXY-1-METHYLPROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:245728-73-8 SDS

245728-73-8Relevant articles and documents

Stereoselective chemoenzymatic synthesis of both enantiomers of protected 4-amino-2-pentanone

Besse, Pascale,Ciblat, Stephane,Canet, Jean-Louis,Troin, Yves,Veschambre, Henri

, p. 2213 - 2224 (1999)

An acetal protected 4-amino-2-pentanone was synthesised by two different routes in 10 and seven steps, respectively, the key step being a microbiological reduction. Both enantiomers of the amine were obtained enantiomerically pure.

MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF

-

Paragraph 256, (2019/05/30)

The present disclosure describes novel TRK kinase inhibitors and methods for preparing them. The pharmaceutical compositions comprising such TRK kinase inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders are also described.

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs

Carocci, Alessia,Catalano, Alessia,Bruno, Claudio,Lentini, Giovanni,Franchini, Carlo,De Bellis, Michela,De Luca, Annamaria,Camerino, Diana Conte

scheme or table, p. 299 - 307 (2010/10/21)

New chiral mexiletine analogs were synthesized in their optically active forms and evaluated in vitro as use-dependent blockers of skeletal muscle sodium channels. Tests carried out on sodium currents of single muscle fibers of Rana esculenta demonstrated

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