246029-02-7

Basic information

• Product Name: 5-FLUORO-7-HYDROXYBENZOFURAN
• Synonyms: 5-FLUORO-7-HYDROXYBENZOFURAN;7-Benzofuranol,5-fluoro-(9CI);5-fluoro-7-Benzofuranol
• CAS NO: 246029-02-7
• Molecular Formula: C8H5FO2
• Molecular Weight: 152.12
• Product Categories: HALIDE
• Mol File: 246029-02-7.mol

Chemical Properties

• Boiling Point: 256.7 °C at 760 mmHg
• Flash Point: 109 °C
• Appearance: /
• Density: 1.395 g/cm³
• Vapor Pressure: 0.00946mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 5-FLUORO-7-HYDROXYBENZOFURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-7-HYDROXYBENZOFURAN(246029-02-7)
• EPA Substance Registry System: 5-FLUORO-7-HYDROXYBENZOFURAN(246029-02-7)

Safety Data

• Hazardous Substances Data: 246029-02-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
5-FLUORO-7-HYDROXYBENZOFURAN is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structural features make it a valuable component in the development of new compounds with potential therapeutic and pesticidal properties.
Used in Drug Discovery and Development:
Due to its structural features, 5-FLUORO-7-HYDROXYBENZOFURAN may have potential biological activities and can be used in drug discovery and development. Researchers can explore its potential as a precursor for the creation of new drugs with improved efficacy and selectivity.
Used in the Pharmaceutical Industry:
5-FLUORO-7-HYDROXYBENZOFURAN is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique properties allow for the development of new drugs with novel mechanisms of action and potential therapeutic benefits.
Used in the Agrochemical Industry:
5-FLUORO-7-HYDROXYBENZOFURAN is also used as a building block in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structural features can contribute to the development of more effective and environmentally friendly agrochemicals.

InChI:InChI=1/C8H5FO2/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,10H

Upstream product

• 246029-00-5 5-fluoro-7-methoxybenzofuran 
• 1481-27-2 4-Fluoro-2-hydroxyacetophenone 
• 51788-80-8 1-(4-fluoro-2-methoxy-phenyl)-ethanone 
• 450-93-1 2-methoxy-4-fluorophenol 
• 246028-99-9 1-(2,2-diethoxyethoxy)-4-fluoro-2-methoxybenzene 
• 253429-19-5 5-fluoro-7-bromo-benzo(b)furan 

Relevant articles and documents

1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS

A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines

N-Aryloxylethylindolealkylamines (5) having dual 5-HT transporter and 5-HT1A affinity are described. These compounds represent truncated analogues of our previously reported piperidinyl derivatives (3). Compounds in this investigation were found to have more similar affinities and functional activities for the 5-HT1A receptor and 5-HT transporter. Though 5-HT1A antagonism is not consistently observed throughout series 5, several molecular features were found to be essential to obtain high and balanced activities. The proper placement of a heteroatom in the aryl ring and the length of the linkage used to tether the indole moiety had significant influence on 5-HT1A and 5-HT transporter affinities. Introduction of a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT1A antagonists. Compounds 33 and 34 were observed to be full 5-HT1A antagonists with Ki values of approximately 30 nM for the 5-HT1A receptor and Ki values of 5 and 0.5 nM for the 5-HT transporter, respectively. Unfortunately, similar to our previous series (3), compounds in this report also had high affinity for the α1 receptor.