Preparation of acid-resistant heavy fluorous tags for recycling in synthetic systems
Acid-resistant heavy fluorous tags, in which all three fluorous chains are tethered in a symmetric manner by carbon-carbon linkage, were designed and synthesized from ethyl crotonate. They were designed also to possess a reactive OH group at a central position, not only for conjugation with a target molecule but also for tag recycling. The tag with an alkyl spacer equipped the primary OH group had the greatest reactivity in conjugation reactions with target molecules and could be recovered in the highest yields, implying its potential for use in recycling applications.
Preparation of acid-resistant heavy fluorous tags for recycling in synthetic systems
Acid-resistant heavy fluorous tags, in which all three fluorous chains are tethered in a symmetric manner by carbon-carbon linkage, were designed and synthesized from ethyl crotonate. They were designed also to possess a reactive OH group at a central position, not only for conjugation with a target molecule but also for tag recycling. The tag with an alkyl spacer equipped the primary OH group had the greatest reactivity in conjugation reactions with target molecules and could be recovered in the highest yields, implying its potential for use in recycling applications.
C-glycoside analogs and methods for their preparation and use
The invention provides versatile sialic acid C-glycoside precursors that are useful for preparing C-glycoside analogs of Gangliosides, peptides, and proteins, as well as synthetic intermediates useful for the preparation of the precursors, and synthetic m
-
(2008/06/13)
Synthesis of a versatile neuraminic acid 'C'-disaccharide precursor for the synthesis of C-glycoside analogues of gangliosides
-
Bazin, Helene G.,Du, Yuguo,Polat, Tuelay,Linhardt, Robert J.
p. 7254 - 7259
(2007/10/03)
More Articles about upstream products of 247027-79-8