Enantioselective synthesis of coumarin derivatives by PYBOX-DIPH-Zn(II) complex catalyzed Michael reaction
A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)2 complex. The methodology has successfully been employed in the synthesis of (R)-Warfarin and another related compounds.
Enantioselective synthesis of coumarin derivatives by PYBOX-DIPH-Zn(II) complex catalyzed Michael reaction
A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)2 complex. The methodology has successfully been employed in
Ray, Sumit K.,Singh, Pradeep K.,Molleti, Nagaraju,Singh, Vinod K.
p. 8802 - 8808
(2013/01/15)
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