247056-24-2Relevant articles and documents
Derivatives of 3-cyano-6-phenyl-4-(3'-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity
Krauze, Aivars,Germane, Skaidrite,Eberline S, Ojars,Sturms, Igors,Klusa, Vija,Duburs, Gunars
, p. 301 - 310 (2007/10/03)
3-Cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione, the related 2,2'- bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05-0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg.