- Acylzirconocene chloride as an 'unmasked' acyl anion: Enantioselective 1,2-addition to α,β-unsaturated ketone derivatives
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The chiral monodentate phosphane ligand (R)-MOP facilitated the first enantioselective nucleophilic 1,2-addition of an 'unmasked' acyl anion to a carbonyl group in the Pd(II)-catalyzed reaction of α,β-unsaturated ketones with acylzirconocene chlorides [Eq
- Hanzawa, Yuji,Tabuchi, Nobuhito,Saito, Kosuke,Noguchi, Satoshi,Taguchi, Takeo
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- Pd-catalyzed regioselective acylation of α,β-unsaturated ketone derivatives by acylzirconocene chloride as an acyl group donor
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Acylzirconocene chlorides reacted with α,β-unsaturated ketones (α,β-enone or -ynone) to give regioselectively 1,2- or 1,4-products under Pd-catalyzed conditions. In the reactions of α,β-enones, excellent regioselectivity was attained by the choice of the
- Hanzawa, Yuji,Tabuchi, Nobuhito,Narita, Kensuke,Kakuuchi, Akito,Yabe, Masaya,Taguchi, Takeo
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p. 7559 - 7571
(2007/10/03)
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