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3-Bromo-4-methoxybenzylamine, with the molecular formula C8H10BrNO, is a chemical compound belonging to the class of organic compounds known as benzylamines. It features a benzene ring with one bromine, one methoxy, and one amine substituent. 3-BROMO-4-METHOXYBENZYLAMINE has a molecular weight of 216.07 g/mol and is widely used in the chemical and pharmaceutical industry as an intermediate for synthesis processes. Due to its potential health and environmental hazards, it is crucial to handle 3-Bromo-4-methoxybenzylamine with care.

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  • 247254-47-3 Structure
  • Basic information

    1. Product Name: 3-BROMO-4-METHOXYBENZYLAMINE
    2. Synonyms: 3-BROMO-4-METHOXYBENZYLAMINE;RARECHEM AL BW 0769;[[3-Bromo-4-(methyloxy)phenyl]methyl]amine;3-Bromo-4-methoxy-benzenemethanamine;(3-bromo-4-methoxyphenyl)methanamine
    3. CAS NO:247254-47-3
    4. Molecular Formula: C8H10BrNO
    5. Molecular Weight: 216.08
    6. EINECS: N/A
    7. Product Categories: Anilines, Aromatic Amines and Nitro Compounds
    8. Mol File: 247254-47-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 290.249°C at 760 mmHg
    3. Flash Point: 129.338°C
    4. Appearance: /
    5. Density: 1.444g/cm3
    6. Vapor Pressure: 0.002mmHg at 25°C
    7. Refractive Index: 1.57
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: N/A
    10. CAS DataBase Reference: 3-BROMO-4-METHOXYBENZYLAMINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-BROMO-4-METHOXYBENZYLAMINE(247254-47-3)
    12. EPA Substance Registry System: 3-BROMO-4-METHOXYBENZYLAMINE(247254-47-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 247254-47-3(Hazardous Substances Data)

247254-47-3 Usage

Uses

Used in Chemical Industry:
3-Bromo-4-methoxybenzylamine is used as a chemical intermediate for the synthesis of various compounds. Its unique structure with a bromine atom and methoxy group allows for versatile reactions and transformations, making it a valuable component in the production of specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 3-Bromo-4-methoxybenzylamine serves as a key intermediate in the synthesis of drugs. Its presence in the molecular structure can contribute to the development of new therapeutic agents, potentially leading to advancements in medicine and healthcare.
Used in Research and Development:
3-Bromo-4-methoxybenzylamine is also utilized in research and development settings, where it can be employed to study the effects of different substituents on the chemical properties and reactivity of benzylamines. This knowledge can be instrumental in designing new molecules with specific characteristics and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 247254-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,7,2,5 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 247254-47:
(8*2)+(7*4)+(6*7)+(5*2)+(4*5)+(3*4)+(2*4)+(1*7)=143
143 % 10 = 3
So 247254-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H10BrNO/c1-11-8-3-2-6(5-10)4-7(8)9/h2-4H,5,10H2,1H3

247254-47-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-bromo-4-methoxyphenyl)methanamine

1.2 Other means of identification

Product number -
Other names {[3-bromo-4-(methyloxy)phenyl]methyl}amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:247254-47-3 SDS

247254-47-3Relevant articles and documents

Discovery of EBI-907: A highly potent and orally active B-RafV600Einhibitor for the treatment of melanoma and associated cancers

Lu, Biao,Cao, Hu,Cao, Jingsong,Huang, Song,Hu, Qiyue,Liu, Dong,Shen, Ru,Shen, Xiaodong,Tao, Weikang,Wan, Hong,Wang, Dan,Yan, Yinfa,Yang, Liuqing,Zhang, Jiayin,Zhang, Lei,Zhang, Lianshan,Zhang, Minsheng

, p. 819 - 823 (2016/05/24)

A novel series of pyrazolo[3,4-c]isoquinoline derivatives was discovered as B-RafV600Einhibitors through scaffold hopping based on a literature lead PLX4720. Further SAR exploration and optimization led to the discovery of potent B-RafV600

Dual Pharmacophores - PDE4-Muscarinic Antagonistics

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Page/Page column 64, (2009/08/18)

The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases.

Dual Pharmacophores - PDE4-Muscarinic Antagonistics

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Page/Page column 67, (2009/08/18)

The present invention relates to novel compounds of Formula (I) and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

Dual Pharmacophores - PDE4-Muscarinic Antagonistics

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Page/Page column 72, (2009/08/16)

The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS

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Page/Page column 152, (2009/10/09)

The present invention is directed to novel compounds of Formula's (I) - (VI), and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of and/or prophylaxis of respiratory diseases, including inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

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