247569-72-8Relevant articles and documents
Preparation method for 3-chloro-4-methoxybenzylamine hydrochloride
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Paragraph 0003; 0013-0016, (2018/09/08)
The invention discloses a preparation method for 3-chloro-4-methoxybenzylamine hydrochloride. The method uses 4-methoxybenzylamine as a raw material, a reaction is performed with sulfonyl chloride inan acetic acid solvent at room temperature, and recrystallization is performed for purification, wherein a molar ratio of the 4-methoxybenzylamine to the sulfonyl chloride is 1:1.02. The improved method provided by the invention has the characteristics of few by-products, mild reaction conditions, low energy consumption, a high yield and high purity.
TROPANE COMPOUNDS
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Page/Page column 373, (2009/05/30)
A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
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, (2008/06/13)
Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.