24762-44-5

Basic information

• Product Name: TRI(PHENYL-D5)PHOSPHINE
• Synonyms: TRIPHENYLPHOSPHINE-D15;TRI(PHENYL-D5)PHOSPHINE;TRI(PHENYL-D5)PHOSPHINE, 99 ATOM % D;tris(2,3,4,5,6-pentadeuteriophenyl)phosphane
• CAS NO: 24762-44-5
• Molecular Formula: C₁₈H₁₅P
• Molecular Weight: 277.38
• Product Categories: Alphabetical Listings;Stable Isotopes
• Mol File: 24762-44-5.mol

Chemical Properties

• Melting Point: 78-80 °C(lit.)
• Boiling Point: 377 °C
• Flash Point: 220℃
• Appearance: /
• Storage Temp.: Room Temperature
• Solubility: Chloroform (Slightly), Hexanes (Slightly)
• CAS DataBase Reference: TRI(PHENYL-D5)PHOSPHINE(CAS DataBase Reference)
• NIST Chemistry Reference: TRI(PHENYL-D5)PHOSPHINE(24762-44-5)
• EPA Substance Registry System: TRI(PHENYL-D5)PHOSPHINE(24762-44-5)

Safety Data

• Hazard Codes: Xn,N
• Statements: 20/21/22-36/37/38-50/53
• Safety Statements: 45-61-60
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 24762-44-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
TRI(PHENYL-D5)PHOSPHINE is used as a synthetic reagent for the synthesis of Chlorambucil, a compound with cytotoxicity in breast and pancreatic cancers. It aids in the development of pharmaceuticals targeting these specific types of cancer.
Used in Antioxidant Research:
TRI(PHENYL-D5)PHOSPHINE is used as a precursor in the preparation of α-Tocopherol analogues, which are essential for monitoring antioxidant status in various applications. This helps in understanding and managing oxidative stress and its related health issues.
Used in Mechanistic Studies:
TRI(PHENYL-D5)PHOSPHINE is employed in a mechanistic study of cis-bis(silylmethyl)platinum(II) complexes. This application contributes to the understanding of the structure, properties, and potential applications of these complexes in various fields, including catalysis and material science.

Upstream product

• 7379-67-1 d₅-iodobenzene 
• 1076-43-3 benzene-d6 
• 4165-57-5 bromobenzene-d5 

Downstream Products

• 54964-93-1 triphenylphosphane oxide-d15 
• 72142-99-5 bis-pentadeuteriophenyl-phosphane 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 75-07-0 acetaldehyde 
• 50-00-0 formaldehyd 
• 137465-32-8 oxotrichlorobis(triphenylphosphine-d15)rhenium(V) 
• 603-35-0 triphenylphosphine 

Relevant articles and documents

[ReF6]2-: A robust module for the design of molecule-based magnetic materials

A facile synthesis of the [ReF6]2- ion and its use as a building block to synthesize magnetic systems are reported. Using dc and ac magnetic susceptibility measurements, INS and EPR spectroscopies, the magnetic properties of the isolated [ReF6]2- unit in (PPh4)2[ReF6]?2H2O (1) have been fully studied including the slow relaxation of the magnetization observed below ca. 4 K. This slow dynamic is preserved for the one-dimensional coordination polymer [Zn(viz)4(ReF 6)]1 (2, viz=1-vinylimidazole), demonstrating the irrelevance of low symmetry for such magnetization dynamics in systems with easy-plane-type anisotropy. The ability of fluoride to mediate significant exchange interactions is exemplified by the isostructural [Ni(viz)4(ReF6)]1 (3) analogue in which the ferromagnetic NiII-ReIV interaction (+10.8 cm-1) dwarfs the coupling present in related cyanide-bridged systems. These results reveal [ReF6]2- to be an unique new module for the design of molecule-based magnetic materials.

Zwitterionic stabilization of a reactive cobalt tris-isocyanide monoanion by cation coordination

A break with tradition: The cation, [Ph3P=N=PPh 3]+ ([PPN]+), was found to provide a stabilizing η2-arene interaction to the coordinatively unsaturated, tris-isocyanide monoanion, [Co(CNArMes2) 3]-(ArMes2=2,6-(2,4,6-Me3C 6H2)C6H3); Co=purple, N=light purple, and P=orange). The resulting zwitterion is a source of [Co(CNAr Mes2)3]- anions, performing nucleophilic additions, carbon-element bond activations, and multistep decarbonylations.

Sequestered alkyllithiums: Why phenyllithium alone is suitable for betaine-ylide generation

The key step in the trans-selective modification of the Wittig reaction is the α-lithiation of the lithium bromide coordinated ylide - aldehyde adduct (the so-called "P-betaine"). Only phenyllithium effects this deprotonation rapidly and cleanly. Alkyllithiums (in particular, butyl-, sec-butyl-, and tert-butyllithium) react only sluggishly and incompletely, being tied up in very stable mixed aggregates with the lithium alkoxide part of the betaines.